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#1 Case study report: Neridronate Treatment for CRPS in ankle for 11 months

General detailsPatient’s info
Age:55 years at the time of treatment
Home Country:U.S.A.
Duration of illness:11 months prior to the Neridronate Treatment
Cause:Left ankle surgery
Symptoms:Tingling and burning pain at the top and the bottom of the foot, it increases with activities; color changes in the limb; slower nails growth; tremors; vertigo
Clinical evaluation:CRPS diagnosis. Existing systemic symptoms along with the ones of the foot. Mild diffused muscle atrophy of the foot and lower leg, discoloration ranging from very red to Cyanosis, shiny skin, brittle flaking nails. Dysesthesia, hyperhidrosis on the sole of the foot. The pain doctor suspected a central process such as multiple sclerosis.
Period of treatment in Italy:June 2022


The patient tried 3 different treatments before all lasting for several sessions, which did not help. She took pain medications which brought just very mild relief, that was never lasting.
The lady personally met a previous MTI patient that underwent Neridronate Treatment for CRPS and reported her good experience and outcomes.



Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website:
4 Pantoprazole infusions; Paracetamol; Prednisone.

2 sessions, 2 hours each, of Neuromuscular Rehabilitation Treatment with the Osteopath and Physiotherapist doctors.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

8 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.



  • DAY 1: arrival at the Venice airport, meeting with the personal Health Planner and short drive to the Vicenza hotel. Check in, briefing focused on the next treatment days, rest. Light therapy and Biophysical treatment in the hotel room.
  • DAY 2: meeting with the Health Planner, visit with the Doctor (the Rheumatologist Professor), first Neridronate infusion, Rehabilitation session. The patient feels well, no side effects, she actively cooperates with the therapists. Light therapy and Biophysical treatment in the hotel room.
  • DAY 3: meeting with the Health Planner, second Neridronate infusion. The patient feels well and comfortable, no side effects. Light Therapy and Biophysical treatment in the hotel room.
  • DAY 4: meeting with the Health Planner, follow up visit with Rheumatologist Professor and third Neridronate infusion. The patient stays in a very good mood and reports light side effects such as skin
    rushes and a bit of neck ache. The Professor prescribes Prednisone to control them. Light Therapy and Biophysical treatment in the hotel room.
  • DAY 5: meeting with the Health Planner, the patient feels better, no more skin rushes and neck pain.
    She is in a very good mood. The Health Planner drives her and her husband on a trip to Garda Lake and Sirmione. Once they are back at the hotel, she just feels a bit tired. Light Therapy and Biophysical treatment in the hotel room.
  • DAY 6: meeting with the Health Planner, fourth Neridronate infusion; rehabilitation session where the patient and the therapists can appreciate improvements in the exercises and the motion range. She
    feels well and the Health Planner shows her and her caregiver around Verona. Light Therapy and Biophysical treatment in the hotel room.
  • DAY 7: rest day, keeping in contact with the Health Planner. The patient feels well and spends the day at the hotel’s pool. Light Therapy and Biophysical treatment in the hotel room.
  • DAY 8: meeting with the Health Planner, check out at the hotel in Vicenza and check in at the Venice hotel. The patient feels well, no side effects, she walks around Venice.
  • DAY 9: meeting with the Health Planner, covid testing and guided visit of Venice. The patient feels well.
  • DAY 10: meeting with the Health Planner and drop-off at the Venice airport to fly back home.



AUGUST 2022 (2 months after treatment): the patient reported 40%-50% reduction of pain, skin redness and dysesthesia.

SEPTEMBER 2022 (3 months after treatment): the patient reduced her daily dose of medications, improved her range of motion and daily activities.

OCTOBER 2022 (4 months after treatment): the patient tried to get off all medications but went back to only 1 pill at night. She could perform many more activities.

FEBRUARY 2023 (9 months after treatment): the patient reported a reduction of pain and symptoms of 60% – 70%. She could go back to most of her activities, including skiing. She still referred a mild pain when she was overworking, quickly resolvable by just resting, no need for medications.



The patient experienced very good outcomes after the Neridronate treatment in Italy, she reported 60% – 70% of pain and symptoms reduction.

According to data and studies, even better results could have been reached if she was treated earlier.

The Neridronate treatment is demonstrated to be more effective if it is done no later than 6 months from the onset of the disease.

In case of long-lasting disease, important improvements can still be expected. Side treatments (such as Physiotherapy, Light Therapy, Biophysical Therapy) are important to boost the Neridronate’s action.

In case of long lasting CRPS, it is suggested to use the side therapies for a longer period of time to maximize the results.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.

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