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CRPS Treatment: pain in arm for 8 years

General details and patient's info

Age:39 years old at the time of treatment.
Home Country:USA.
Illness duration:8 years prior to the Neridronate Treatment.
Symptoms:Intense pain in all arm and shoulder, she describes as 10/10, daily. Burning sensation in arm. Pins and needles sensation. Swelling of the hand. Change in color of arm.
Clinical evaluation:Complex Regional Pain Syndrome. Color change and swelling noted during visit.
Time of treatment:July 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

Looking online for diverse types of treatment, she came across our website and read all the information’s for month until, been offered by her doctor only choices requiring surgical intervention, she decided to contact us.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Pantoprazole infusions; Paracetamol.

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in the hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

8 nights Biophysical Treatment (5 hours each night while the patient is asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Visit with Biologist Nutritionist: a specialist in the modulation of the Intestinal Microbiota as per precision and gender medicine. Through the reading of blood chemistry tests performed at the facility, the goal is to identify deficiencies at the level of micro-nutrients, enzymatic, metabolic imbalances, which is fundamental for the proper functioning of our intestine and our immune system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 4: Morning pick-up by her Patient Manager, 2nd Neridronate infusion.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion. In the afternoon, quick touring of Verona, as the patient feels very tired.

DAY 6: Touristic afternoon in Lake Garda. Patient mentioned having a light headache in the end of the day.

DAY 7: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion. The patient feels much better so, in the afternoon, tourism of Soave’s Castle.

DAY 8: Rest day, in contact with her Patient Manager. The patient highly appreciate the light therapy as she says it brought her relief during her stay in Italy.

DAY 9 : Pick-up by her Patient Manager and drop-off at Venice airport.

Follow up

AGUST 2023 (1 month after Neridronate treatment): patient says she thinks she feels some small reduction in her pain.

DECEMBER 2023 (5 months after Neridronate treatment): the swelling has reduced, and the redness disappeared. Pain level is still 5/10.

FEBRUARY 2024 (7 months after treatment): Patient says both redness and swelling are now gone. Range of motion has improved, her pain levels are now between 2/10 and 3/10, which she is very grateful for.


In CRPS cases of longer duration – 8 years in this case-, the results from the treatment are highly connected to the use of a multidisciplinary approach. For this patient, all side therapies were advised, as well as a visit with our Biologist Nutritionist in order to help the patient understand the level of inflammation in her body and create a nutrition plan that will help her reduce it.
For a patient living with constant 10/10 pain, reaching a 2/10 or 3/10 like this patient is a life-changing improvement.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.