Dowload our free ebook: your guide to CRPS filled with incredible knowledge on the condition

CRPS Treatment: pain in both arms and legs for 11 years

General details and patient's info

Age:57 years old at the time of treatment.
Home Country:USA.
Illness duration:11 years prior to the Neridronate Treatment.
Cause:Skiing accident.
Symptoms:Burning pain, legs are swollen, pins and needles legs and arms, cannot walk (uses a wheelchair), hair growth abnormal on legs.
Clinical evaluation:CRPS diagnosis. Symptoms are stronger in the legs (triggering event was a shinbone fracture). CPRS developed in the arms 3 years after original onset.
Time of treatment:September 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient heard about us on a Facebook support group, after which he joined our own private support group and talked to a few of our previous patients, who convinced him to give the treatment a try. He then contacted us and was in Italy within a month. 

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
4 Clodronate infusions (300mg, IV in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website:

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

6 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

6 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate and Clodronate infusions.

DAY 3: Morning pick-up by his Patient Manager, 2nd Neridronate and Clodronate infusions.

DAY 4: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd Neridronate and Clodronate infusions. Touring of Verona.

DAY 5: Rest day in the hotel, in contact with his Patient Manager.

DAY 6: Morning pick-up by his Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate and Clodronate infusions.

DAY 7: Pick-up by his Patient Manager, check-out and drop-off at the Venice airport for his trip back home.

Follow up

NOVEMBER 2023 (2 months after Neridronate treatment): the patient reports feeling “stronger” in his legs.

JANUARY 2023 (4 months after Neridronate treatment): the patient reports that he took his first 5min walk in about 6 years, without the wheelchair. His pain levels have decreased from 8 or 9/10 to 6 or 7/10.

FEBRUARY 2023 (5 months after Neridronate treatment): the patient reports being able to move around without the wheelchair pretty often now, he says his pain levels are down to 4 or 5/10 and the swelling in his legs is completely gone now.


In long CRPS cases such as this one, the multidisciplinary approach and 360° treatment we have created around this patient is essential.
This patient is now able to walk without the need of a wheelchair in most occasions, which led him to being able to get back into society, from which he was getting excluded slowly. We are very happy to see his results from the treatment, after long years of suffering, and appreciated a 50% pain reduction.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.