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CRPS Treatment: pain in both arms for 3 years

General details and patient's info

Age:67 years old at the time of treatment.
Home Country:USA.
Illness duration:3 years prior to the Neridronate Treatment.
Cause:Surgery on left wrist.
Symptoms:Pain he describes as stabbing and sets at 8/10 daily; burning sensation; sensitivity to weather change; sensitivity to touch; sensitivity to vibrations.
Clinical evaluation:CRPS. 
Time of treatment:October 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient’s daughter found us online while looking for CRPS treatment for her father.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
9 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
9 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by his Patient Manager, 2nd infusions.

DAY 5: Rest day in the hotel, in contact with his Patient Manager.

DAY 6: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 7: Morning pick-up by his Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8-9: Rest days in the hotel, in contact with his Patient Manager.

DAY 10: Pick-up by his Patient Manager, check-out, and drop-off at the Verona train station, as the patient has planned a trip around Italy for the next 2 weeks.

Follow up

JANUARY 2020 (3 months after Neridronate treatment): The patient refers to his pain changing, saying the type of pain feels different, which is completely normal after the Neridronate treatment. He says the burning sensation has gone less aggressive.

MARCH 2020 (5 months after Neridronate treatment): Patient is slowly gaining his strength back in both arms, he says he would place his pain level at 6/10.

JUNE 2020 (8 months after Neridronate treatment): Patient put his pain level at 4/10 and is incredibly grateful for treatment. The extreme sensitivity that was present on his arms has now reduced by 80%, according to the patient.


Neridronate taking care of the root issue of CRPS, it not only helps with the pain, but also on the other symptoms. As it is the case with this patient, who suffered from a very high sensitivity to touch, weather change and vibrations. Post-treatment, that sensitivity had gone down 80%, as well as a 50% improvement of pain level.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.