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CRPS Treatment: pain in both feet and legs for 1 year and a half

General details and patient's info

Age:21 years old at the time of treatment.
Home Country:United States of America.
Illness duration:16 months prior to the Neridronate Treatment.
Cause:L5 fracture, slip disc.
Symptoms:Burning and throbbing pain in both legs, deep bone pain. Sharp nerve pain shooting through entire body. Walking is very hard and she needs a walker, standing, sitting too long trigger more pain in back and legs. Long time bedbound. Sun or hot showers bring skin rash all over the body. Exercise increases pain.
Clinical evaluation:CRPS diagnosis.
Time of treatment:October 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient underwent 2 different treatments and took a lot of different pain medications with mild results before coming to Italy. She watched “House Hunter International” about an American woman moving to Vicenza – Italy to get medical treatments for CRPS, after which her mother got in touch with MTI.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website:
4 Pantoprazole infusions; Paracetamol;

2 sessions, 2 hours each, of Neuromuscular Rehabilitation Treatment with the Osteopath and Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

6 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Vicenza train’s station, greeted by her Patient Manager, followed by check-in at her Hotel in Vicenza. Briefing focused on next days. Light therapy has been installed in her hotel room; her Patient Manager has explained all details on how to operate the machine.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Neridronate infusion, 1stRehabilitation session. The patient is tired but cooperates especially with the osteopath and physiotherapist doctors, she appreciates the session. She then proceeds with Light therapy in her hotel room.

DAY 3: Morning pick-up by her Patient Manager, 2nd infusion, visit of Vicenza. The patient feels tired, and she sleeps during the infusion. She then proceeds with Light therapy in her hotel room.

DAY 4: Morning pick-up by her Patient Manager and 3rd infusion. The patient feels very sleepy as she is dealing with jetlag. She then proceeds with Light therapy in her hotel room.

DAY 5: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, last Neridronate infusion and 2nd Rehabilitation session. The patient is still tired, but she is very happy about the Rehabilitation program. She then proceeds with Light therapy in her hotel room.

DAY 6: Morning pick-up by her Patient Manager and day trip to Venice. She then proceeds with Light therapy in her hotel room.

DAY 7: Morning pick-up by her Patient Manager, drop-off at Padova train station.

Follow up

DICEMBER 2019 (2 months after treatment: no more discoloration and skin rush. The patient feels better, and she even started a job. She keeps on exercising following the Rehabilitation plan and suggestions given by our Doctors in Italy.

APRIL 2020 (6 months after treatment): the patients refers important progress and improvements, no more pain, she is walking again and enjoying her life.

OCTOBER 2020: (1 year after treatment): the young girl is in full remission, completely active. She is back to running and sports.

AUGUST 2021 (22 months after treatment): the patient is in full remission.

FEBRUARY 2022 (28 months after treatment): the patient is in full and lasting remission. She was so impressed by the rehabilitation sessions in Italy, and the influence of the exercises on her body, that she decided to start studying Physiotherapy and now works in the Physiotherapy field herself.


The patient went into full lasting remission. This young girl was very sporty, which is why she really enjoyed the Rehabilitation sessions in Italy and appreciated their effect. When she went back home, she followed MTI Osteopath and Physiotherapist exercises scheme correctly, on a regular base, which played a very important part in her remission.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.