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CRPS Treatment: pain in both legs and arms for 5 years

General details and patient's info

Gender:Female.
Age:26 years old at the time of first treatment, 27 at the time of second treatment.
Home Country:United States of America.
Illness duration:5 years prior to the Neridronate Treatment.
Cause:Separation of ligament from bone in right ankle.
Symptoms:Ankle shows change in color and excessive sweating; symptoms worsen with cold and heat; irregular hair and fingernails growth; high sensitivity in both feet, legs, hands and arms; muscle weakness; pain worsens with activities, weight bearing, pressure; insomnia due to intensification of pain during the night.
Clinical evaluation:CRPS diagnosis.
Time of treatment:1st treatment : September 2018 / 2nd treatment : July 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient, before her first Neridronate treatment in Italy, was followed by a pain management clinic and tried 5 different therapies. Patient is allergic to common pain medication. She had very good results from first cycle of Neridronate, and she decided to undergo the treatment once again after one year to strengthen the outcomes. The Rheumatologist Professor prescribed, for the second cycle, only 2 Neridronate infusions.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

FIRST TREATMENT
4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

SECONDTREATMENT
2 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

2 sessions, 2 hours, of Neuromuscular Rehabilitation Treatment with the Osteopath and Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

SECOND TREATMENT

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager and check-in in the hotel in Vicenza. Light therapy has been installed in her hotel room; her Patient Manager has explained all details on how to operate the machine.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor and 1st Neridronate infusion. The patient’s veins are hard to find but she is doing well. The patient reports some mild nausea. She then proceeds with Light therapy in her hotel room.

DAY 3: Morning pick-up by her Patient Manager, 1st rehabilitation session. The patient feels better, and she is up for a short tour of Vicenza’s city center. She then proceeds with Light therapy in her hotel room.

DAY 4: Morning pick-up by her Patient Manager, day trip to Padova’s city center, the patient feels well. She then proceeds with Light therapy in her hotel room.

DAY 5: Morning pick-up by her Patient Manager, 2nd Neridronate infusion and 2nd visit with the Rheumatologist Professor. Shopping time! It’s July 4th, so the patient and her caregiver attend the celebrations at the American Army Camp: Ederle base in Vicenza. She then proceeds with Light therapy in her hotel room.

DAY 6: Morning pick-up by her Patient Manager, 2nd rehabilitation session and visit of Soave city. She then proceeds with Light therapy in her hotel room.

DAY 7: Morning pick-up by her Patient Manager, day trip to Verona and patient’s birthday celebration with MTI team in the evening. She then proceeds with Light therapy in her hotel room.

DAY 8: Morning pick-up by her Patient Manager, check-out Vicenza’s Hotel and check-in Venice Hotel.

DAY 9: Free day in Venice, in contact with her Patient Manager

DAY 10: Morning pick-up by her Patient Manager and drop-off at the Venice airport.

Follow up

JANUARY 2023 (3 years after second treatment): after her second round of treatment, the patient was able to start running again. She ran her first 10-mile race without stopping, got back into snowboarding, hiking, biking, and other exercise classes.

Conclusion

This young lady suffered from CRPS for 5 years and she had very good results with pain and sensitivity decrease after her first round of infusions, which pushed her to come back for a second round, a year after, to try getting even further results.
She is now back to her life, running marathons, climbing mountains and snowboarding !

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.