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CRPS Treatment: pain in both legs for 9 years

General details and patient's info

Age:48 years old at the time of treatment.
Home Country:New Zealand.
Illness duration:9 years prior to the Neridronate Treatment.
Cause:Knee surgery on right leg.
Symptoms:Sharp burning pain; muscle loss; skin sensitivity; sensitive to cold; abnormal nail growth; swelling; color change to purple; skin is very shiny. The patient cannot walk without a wheelchair.
Clinical evaluation:CRPS. Patient’s pain level is described as incredibly high, she puts it 9/10 daily. 
Time of treatment:October 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

This patient had tried so many treatments, flew in different countries to see the best doctors and try everything possible to help her CRPS. Although it started in her right leg, it quickly spread to her left leg too. In the past, she had managed to lower the pain levels with some treatments, but it never lasted. She found out about Neridronate while searching online and immediately decided to come to Italy.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

Clodronate infusions.

3 sessions Massotherapy Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

8 nights Biophysical Treatment(5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Visit with Nutritionist;

Visit with Health Coach.

Daily Report

DAY 1: Arrival at the Verona airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions. Visit with Nutritionist.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions. Visit with Health Coach.

DAY 6: Rest day in the hotel, in contact with her Patient Manager.

DAY 7: Morning pick-up by her Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Rest day in the hotel, in contact with her Patient Manager.

DAY 9: Pick-up by her Patient Manager, check-out and drop-off at the Verona airport for her trip back home.

Follow up

FEBRUARY 2024 (4 months after Neridronate treatment): The patient is thoroughly following the diet that was created for her by the nutritionist, and doing the exercises indicated by the Health Coach and the physiotherapist she saw in Italy. She says her pain levels are slowly decreasing and pus them at 6/10 now. Her skin has gotten back to normal; she says the shininess is gone, and she notices the color changes have been less frequent.

APRIL 2024 (6 months after Neridronate treatment): The patient is now walking without the aid of a wheelchair! She is incredibly happy about it, she puts her pain levels at 3/10 and says she has been able to lower the amount of medicine she is taking daily.


This patient was able to appreciate pain reduction from 9/10 to 3/10 daily, which was incredible for her, having been in this much pain for so many years. Being able to walk without the need of a wheelchair was lifechanging for our patient, who then confirmed she was finally able to go back to her workplace.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.