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CRPS Treatment: pain in foot for 11 months

General details and patient's info

Age:50 years old at the time of treatment.
Home Country:U.S.A.
Illness duration:11 months prior to the Neridronate Treatment.
Cause:reconstructive foot surgery.
Symptoms:unbearable pain, swelling, stiffness. With weight bearing sharp, stabbing and burning pain. Unable to walk for 6 months. Medications help her to walk short distance but never after 7pm; she is unable to climb stairs.
Clinical evaluation:CRPS diagnosis after foot surgery in October 2020. Another surgery in December 2020 for the removal of hardware in hope that it could all only be a reactive response by her body: it failed to resolve the pain.
Time of treatment:February 2021.

Why the Patient decided to undergo the CRPS Treatment in Italy

This lady tried about 15 different treatments, with minimum and not appreciable results. She took many medications, some of them, at maximum dosage, brought mental issues and suicidal thoughts. She searched online and on social media groups and then got in touch with people knowing about the Neridronate infusions and their efficacy.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
4 Pantoprazole infusions; Paracetamol.

2 sessions, 2 hours each, of Neuromuscular Rehabilitation Treatment with the Osteopath and Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

6 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager and check-in Vicenza Hotel. Light therapy has been installed in her hotel room; her Patient Manager has explained all details on how to operate the machine.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st rehabilitation session and 1st Neridronate infusion. She then proceeds with the Light therapy in her hotel room.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. Visit to Verona’s City center. The patient feels very tired. She then proceeds with the Light therapy in her hotel room.

DAY 4: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. The patient reports headaches, nausea, and back ache. She then proceeds with the Light therapy in her hotel room.

DAY 5: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, 2nd rehabilitation session, last Neridronate infusion. The patient feels much better than previous days so in the afternoon she agrees to have a tour of Garda Lake and Sirmione. She then proceeds with the Light therapy in her hotel room.

DAY 6: Morning meeting with her Patient Manager and rest day. She then proceeds with the Light therapy in her hotel room.

DAY 7: Morning pick-up by her Patient Manager, check-in at the Venice hotel and touring of the town. No more side effects, she is just a bit tired.

DAY 8:Free day in Venice, always in contact with her Patient Manager. The patient loves Venice; she now needs some rest.

DAY 9: Morning pick-up by her Patient Manager, check-out at hotel and drop-off at Venice airport to fly back home.

Follow up

NOVEMBER 2021 (2 months after treatment): the patient experienced some small improvements; her mood is better, and she has very high expectations about the treatment results.

APRIL 2022 (7 months after treatment): the patient feels much better, pain lowered to bearable levels, and she is back to most of her activities at home, taking care of her family with 4 kids.

JULY 2023(22 months after treatment): the patient is in remission. She is back to her teaching job, standing up for many hours every day.


This patient had CRPS from nearly one year when she underwent Neridronate infusions, it was severe and disabling.
She is now is complete lasting remission and back to her workplace!

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.