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CRPS Treatment: pain in hand and arm for 8 years

General details and patient's info

Age:41 years old at the time of treatment.
Home Country:USA.
Illness duration:8 years prior to the Neridronate Treatment.
Cause:Broken finger on left hand.
Symptoms:Extreme swelling of the hand; skin sensitivity in all the arm; burning pain in the arm; frequent changes in temperature; difficulty in holding objects with left hand due to high levels of pain (usually 9/10 daily, as described by the patient).
Clinical evaluation:CRPS.
Time of treatment:October 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The woman had heard about Neridronate in a Facebook group for CRPS patients. She had a long talk with one of the members who had undergone the treatment himself and ended up booking a call with one of our Patient Care Coordinators the week after. She came to Italy 2 months after.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

4 Pantoprazole infusions; Paracetamol.

3 sessions Massotherapy Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in the hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venezia airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager. The patient is amazed with the light therapy. She says she has never since her hand’s swelling reducing this quickly over the last years.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist, 1st Rehabilitation session, and 1st infusions. Tourism in Verona.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions. Tourism in Soave.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions. Patient feels body aches, Paracetamol taken post infusion.

DAY 6: Rest day in the hotel, in contact with her Patient Manager. Patient goes back to Verona city center on her own for some shopping!

DAY 7: Morning pick-up by her Patient Manager, patient feels better and does not refer to any side effects. 2nd visit with Rheumatologist, 3rd Rehabilitation session, 4th infusions.

DAY 9: Pick-up by her Patient Manager, check-out and drop-off at the Venice airport for her trip back home.

Follow up

DECEMBER 2023 (2 months after Neridronate treatment): patient feels her hand and arm getting stronger every day, she says her swelling has gotten down about 70% and the pain is already decreasing quickly.

MARCH 2023 (5 months after Neridronate treatment): the patient refers to a pain reduction of 90% and swelling nearly completely gone.


In a case such as this one, in which the patient had suffered for over 8 years of CRPS, it is essential to attack the disease from all fonts. Which is why MTI continuously does research in order to implement new treatments and complementary therapies around Neridronate and give the best chances to every patient.
In her case, the multidisciplinary approach really has shown its importance, as she was able to appreciate a 90% in pain reduction, and complete disappearing of her swelling in only 5 months.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.