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CRPS Treatment: pain in hand and wrist for 4 years

General details and patient's info

Age:40 years old at the time of treatment.
Home Country:USA.
Illness duration:4 years prior to the Neridronate Treatment.
Cause:Right wrist fracture.
Symptoms:Sharp, burning pain. Swelling of the hand. Changes of color (red, sometimes purple). Skin texture changes. Hair growth changes. Pain to touch.
Clinical evaluation:Complex Regional Pain Syndrome. High allodynia noted during the visit.
Time of treatment:October 2021.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient’s wife joined several Facebook CRPS support groups in which she saw one of our previous patients talking about her experience with us and her results from the treatment.
Lucky enough, this lady lived in the same city of the couple. They met and after hearing every detail of the treatment, they decided to take the trip for the Neridronate treatment too.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Pantoprazole infusions; Paracetamol.

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in the hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

7 nights Biophysical Treatment (5 hours each night while the patient is asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager. Patient suffer from a little bit of jet lag.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion. The patient is impressed with the physiotherapist’s skills and gentle touch as he had a very bad experience in the USA.

DAY 4: Morning pick-up by his Patient Manager, 2nd Neridronate infusion. In the afternoon, tourism in Verona with his Patient Manager.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion.

DAY 6: Rest day, in contact with his Patient Manager.

DAY 7: Morning pick-up by his Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion. In the afternoon, tourism of Soave’s Castle.

DAY 8: Pick-up by his Patient Manager and drop-off at Venice airport.

Follow up

DECEMBER 2021 (2 months after Neridronate treatment): the patient says the swelling and redness in his hand have drastically reduced. Pain is still present, but on lower levels (6/10 against a constant 10/10 before his treatment). He is following the exercises report given by the physiotherapist in Italy.

FEBRUARY 2022 (4 months after Neridronate treatment): the patient says he does not feel pain due to any material’s touch anymore, and the swelling is completely gone. He said he can wear his favorite bracelet for the first time in 4 years.

MAY 2022 (7 months after treatment): The patient mentions a pain lowering of 85% since his treatment, and confirms the swelling and redness of his hand have not come back since December.


The patient’s case was of a 4 years CRPS battle. In this case, side therapies are always strongly recommended. This patient had incredible results both on pain levels, lowering of 85%, and other symptoms that were very handicapping for him.
This was a very successful case and the patient’s positivity and his dedication to the exercise plan from his neuro-muscular sessions were key in his recovery.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.