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CRPS Treatment: pain in left arm for 6 years

General details and patient's info

Age:40 years old at the time of treatment.
Home Country:New Zealand.
Illness duration:6 years prior to the Neridronate Treatment.
Cause:Shoulder fracture.
Symptoms:Sharp burning pain, going from the hand to the shoulder; very frequent spasms; lack of strength in the arm which is very difficult to use; swelling, sensitivity to touch; always wearing long heavy sleeves and glove to protect the painful limb; afraid of being in a crowd and being touched; after 2 years from the disease onset, the patient developed anxiety, depression and lack of sleep.
Clinical evaluation:Complex Regional Pain Syndrome. 
Time of treatment:August 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

Due to his pain and depression, the patient left his accounting job and he isolated himself from people. It was his wife that convinced him to travel to Italy after she researched on the Neridronate option.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:
4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
4 Pantoprazole infusions; Paracetamol.

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
9 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
9 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at Venice airport, meeting with his Patient Manger, check-in at the Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: 1st visit with the Rheumatologist Professor and 1st infusions. 1st Rehabilitation session. The patient feels tired and suffers the jet lag.

DAY 4: 2nd infusions. The patient feels a bit nauseous.

DAY 5: Day trip to Venice with his Patient Manager. The patient feels much better than previous day.

DAY 6: 3rd infusions and 2nd Rehabilitation session.

DAY 7: 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session and 4th infusions. The patient feels quite well and appreciate the Rehabilitation, which he founds different from that he has at home.

DAY 8: Rest Day, in contact with Patient Manager. The patient feels quite well, and he exercise in the hotel gym according to the physiotherapist doctor suggestions.

DAY 9: Visit of Verona center with Patient Manager.

DAY 10: Check out and drop off Venice airport by Patient Manager.

Follow up

OCTOBER 2023 (2 months after Neridronate treatment): the patient feels that the pain is progressively decreasing, and his mood is improving.

NOVEMBER 2023 (3 months after Neridronate treatment): the patient says his pain levels in some days go to zero and are much manageable in the other days. He is going out with relatives and friends again.

GENNAIO 2024 (5 months after Neridronate treatment): the patient’s wife informs us that he will be back to work in few weeks.

FEBRUARY 2024 (6 months after Neridronate treatment): the patient is back to his job; he feels comfortable with people, and he experiences bad days only time to time only.


This case shows how much and deeply CRPS also affects the mental health of people, their mood, their life. When the pain slows down and the patients may go back to their activities they feel motivated, positive and mental and emotional states will improve.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.