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CRPS Treatment: pain in left foot and leg for 18 months

General details and patient's info

Age:25 years old at the time of treatment.
Home Country:United States of America.
Illness duration:18 months prior to the Neridronate Treatment.
Cause:Broken kneecap .
Symptoms:Throbbing pain in leg, bone pain; burning sensation; walking is extremely painful and difficult; pain is constant but often increasing during the night, sleep is affected.
Clinical evaluation:CRPS diagnosis.
Time of treatment:October 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient was followed by her family doctor and by a pain management clinic. They gave her different medications. She had a mild relief from chiropractic treatments and acupuncture, but the improvements just lasted for a very short time. The patient’s Doctor researched about different options and finally she suggested Neridronate.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

4 Pantoprazole infusions; Paracetamol.

2 sessions, of Neuromuscular Rehabilitation Treatment with the Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
7 nights Biophysical Treatment
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: DAY 1: Arrival at Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Vicenza. Briefing focused on next days.

DAY 2: Rest day to recover from the long journey. In contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st infusions, 1stRehabilitation session. The patient feels quite well and rested, she enjoys the Rehabilitation session and works well with the therapist.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions. The patient feels tired, and she sleeps during the infusion. After that she agrees visiting Vicenza center with her Patient Manager.

DAY 5: Morning pick-up by her Patient Manager, the young girl feels well, and she visits Verona center, able to walk for a couple of hours. After lunch she has her 3rd infusions.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, last infusions and 2nd Rehabilitation session. The patient is very happy about the Rehabilitation program, she feels that it is easier to exercise compared to the first session.

DAY 7: Morning pick-up by her Patient Manager and day trip to Padova, lunch in a typical restaurant then rest.

DAY 8: Pick-up by her Patient Manager, drop-off at Venice airport.

Follow up

DECEMBER 2023 (2 months after Neridronate treatment): the patient says that she keeps on exercising according to the suggestions from the Italian physiotherapist. Her pain levels have slightly improved, and she can finally sleep better at night.

JANUARY 2023 (3 months after Neridronate treatment): the patient refers a decrease of pain, both during the day and the night. She does not need resting every time she walks.

FEBRUARY 2023 (4 months after Neridronate treatment): the patient is experiencing an important decrease of pain, and she can walk longer distances.

APRIL 2023 (6 months after Neridronate treatment): the patient says that her pain level has settled to a 1 or 2 and most days she does not even need pain medications.
APRIL 2024 (1 year and a half after Neridronate treatment): the patient says that she is doing very well, she only had 3 flares up during past year. She can take longer walks now and even is planning a hike next month!


This young patient had always been active and sporty, passionate about climbing. She was comfortable in exercising every day, following the physiotherapy program designed for her in Italy. This consistency together with the Neridronate helped her to reach great and lasting improvements.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.