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CRPS Treatment: pain in left foot and leg for 3.5 years

General details and patient's info

Age:34 years old at the time of treatment.
Home Country:Canada.
Illness duration:3.5 years prior to the Neridronate Treatment.
Cause:Sprained ankle.
Symptoms:Extreme pain the patient says she feels 10/10 pain if she does not take pain medication; extreme allodynia; extreme hyperalgesia; extreme swelling and change in color of the foot.
Clinical evaluation:CRPS. 
Time of treatment:November 2021.

Why the Patient decided to undergo the CRPS Treatment in Italy

This patient presented extremely aggressive CRPS symptoms. She was under a lot of medication in order to help her pain reduce to 7 instead of 10/10. She had tried various treatment with no lasting improvements. She found CRPS-Treatment Italy online and contacted us to understand if she would be eligible for treatment. She was welcomed in Italy 3 months later.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions. Tourism in Soave.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions.

DAY 5: Rest day in the hotel, in contact with her Patient Manager.

DAY 6: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions. Tourism in Verona.

DAY 7: Morning pick-up by her Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Rest day in the hotel, in contact with her Patient Manager. Dinner with MTI’s team!

DAY 9: Pick-up by her Patient Manager, check-out, and drop-off at the Venice airport for her trip back home.

Follow up

MARCH 2022 (4 months after Neridronate treatment): The patient reports her pain levels have lowered to 7/10 daily, she is feeling positive that she will see further improvements in the next months.

JULY 2023 (8 months after Neridronate treatment): The patient says her pain levels are now around 4/10, and she has stopped taking a lot of her daily medication, she can now walk without the use of her cane. All other symptoms have lowered by 70%, according to the patient.


This patient had one of the most extreme cases we had seen, her symptoms were severe, and her pain levels were very high, she needed various medication daily to be able to move, sit, walk and sleep. Taking this much medication had had a toll on her stomach which was under a lot of pain too.
Starting at 10/10, her pain levels have dropped to 4/10, and all other symptoms are 70% less aggressive, which is a huge win for this patient.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.