CRPS Treatment: pain in left foot for 4 years

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CRPS Treatment: pain in left foot for 4 years

Contents

General details and patient's info

Gender:Female.
Age:45 years old at the time of treatment.
Home Country:United States of America.
Illness duration:4 years prior to the Neridronate Treatment.
Cause:Ankle surgery.
Symptoms:Continuous burning pain; allodynia; change of color are frequent. Patient says that her pain levels vary from 5 to 7. She can stand and walk taking frequents breaks.
Clinical evaluation:CRPS localized in the left foot, around the ankle and into the toes. Aggravating factors are standing and walking, elevating the foot. Foot swelling, skin color changes to grayish blue. Left foot is colder than right one. Left foot weakness, decreased range of motion.
Time of treatment:August 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

Following her CRPS onset, the woman had to progressively decrease working until she had to dismiss some of her patients (she is a gynecologist) which was when she decided she could not continue like this. She started to look at every treatment available and found out about Neridronate online.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 Neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

4 Pantoprazole infusions; Paracetamol.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at Verona airport, welcomed by her Patient Manager. She traveled alone from USA. Check in at Verona hotel. Light therapy in the room.

DAY 2: Rest day, in contact with her Patient Manager. She takes a short walk-in town. Light therapy in the hotel room.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor and 1st infusion. Light therapy in the hotel room.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusion. The patient feels quite well, in the afternoon she visits the Valpolicella area with her Patient Manager. Light therapy in the hotel room.

DAY 5: Morning pick-up by her Patient Manager, 3rd infusion. After the infusion she enjoys talking with other Doctors at the clinic, about the differences between the Italian and the American healthcare. Light therapy in the hotel room.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor and last infusion. The patient is glad that she did not have side effects. Light therapy in the hotel room.

DAY 7: The patient feels tired, but she agrees to visit Venice with her Patient Manager. Light therapy in the hotel room.

DAY 8: Pick-up from her Patient Manager, check out and drop off to Venice airport.

Follow up

NOVEMBER 2019 (3 months after the Neridronate treatment): the patient is following the Rheumatologist suggestions and exercising on a regular base. She says that her pain levels are not going over 6 anymore. She is confident in future improvements.

DECEMBER 2019 (4 months after the Neridronate treatment): the patient says that the pain levels usually are around 4/ 10, with several good days of being at 2/10.

JANUARY 2020 (5 months after the Neridronate treatment): the patient says that she can stand longer, which allowed her to get back to working on a busier schedule. The pain levels are gradually decreasing.

MARCH 2020 (7 months after the Neridronate treatment): the patient only has a few “pain days”, which she easily manages with some pain killers, and she generally feels well. Standing, walking, climbing stairs are possible in a comfortable way, for longer time and distance.

Conclusion

This patient had very good outcomes from her treatment in Italy. She was one of the people, being in the “inside”, that made us understand the dramatic differences between the Italian and US healthcare, urging us even more to continue providing access to international patients.
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DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.