CRPS Treatment: pain in left foot for 6 months

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CRPS Treatment: pain in left foot for 6 months

Contents

General details and patient's info

Gender:Male.
Age:40 years old at the time of treatment.
Home Country:Australia.
Illness duration:6 months prior to the Neridronate Treatment.
Cause:Bunion surgery.
Symptoms:Sharp and burning pain on the left foot, unbearable in toes.
Hyperalgesia, allodynia, hyperesthesia. Restricted mobility of left foot.
Clinical evaluation:CRPS.
Time of treatment:January 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

Upon his CRPS diagnosis following the bunion surgery, it was the patient’s podiatric surgeon that suggested he should investigate Neridronate infusions at soonest. Having had another CRPS patient in the past, the surgeon had looked into treatment options and had already informed our patient that remission is very probable for cases undergoing the treatment within the first 12 months of the condition. The patient did not try any other options and travelled here urgently.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 Neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

4 Pantoprazole infusions; Paracetamol.

2 sessions Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

9 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

9 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival in Verona airport, greeted by his patient manager. Drive to Verona hotel, check in, briefing on the next days program. Light therapy and biophysical treatment in hotel room.

DAY 2: Rest day in contact with his patient manager. Light therapy and biophysical treatment in hotel room.

DAY 3: Pick up by his patient manager, first visit with the Rheumatologist Professor, first infusions. Light therapy and biophysical treatment in hotel room.

DAY 4: Pick up by his patient manager, first rehabilitation session and second infusions. Light therapy and biophysical treatment in hotel room. The patient feels tired and a bit nauseous.

DAY 5: Pick up by his patient manager, day trip to Venice. Although the patient could not walk for a very long time, he enjoyed the vaporetto boat, the gondola and the city’s atmosphere. Light therapy and biophysical treatment in hotel room.

DAY 6: Pick up by his patient manager, second rehabilitation session, third infusions. Light therapy and biophysical treatment in hotel room.

DAY 7: Pick up by his patient manager, fourth infusions. Light therapy and biophysical treatment in hotel room.

DAY 8: Pick up by his patient manager, day trip to Garda Lake. The patient walks around taking frequent breaks to rest his foot. Light therapy and biophysical treatment in hotel room.

DAY 9: Very early pick up by his patient manager, drive to Verona airport and flight back to Australia.

Follow up

MARCH 2023 (2 months after the Neridronate treatment): the patient mentions he can walk longer and is more active.

APRIL 2023 (3 months after the Neridronate treatment): the patient says that pain level dropped down between 1 and 3. The allodynia seem to have completely disappear.

JUNE 2023 (5 months after the Neridronate treatment): the patient says he is at 0 pain and has been for a few weeks now. He mentions the rest of his symptoms have also disappeared and says “I consider myself in full remission”.

Conclusion

In this case the patient’s doctor played a very important role: being aware about Neridronate and communicating with his patient is most likely what allowed him to go into full remission. The first year is crucial for this treatment, it is the window of time that has been the most linked to remission for CRPS patients and Neridronate.
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DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.