CRPS Treatment: pain in left hand for 11 years

General details and patient's info

Gender:Male.
Age:38 years old at the time of treatment.
Home Country:United States of America.
Illness duration:11 years prior to the Neridronate Treatment.
Cause:Right foot fracture in a boat accident.
Symptoms:24 hours pain at highest level, especially in fingers. Pain has been worsening in time and slowly made it impossible to use his hand. Burning sensation, cannot stand anything even slightly touching his hand.
Clinical evaluation:CRPS.
Time of treatment:January 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient had to wait nearly 3 years to receive a CRPS diagnosis. After that he met several pain management doctors, tried all possible medications and finally had a pain pump implanted. This unfortunately led to an infection and was removed after only a few months. He had some light relief from physiotherapist sessions, the physician was a family friend and pushed him to research further options out of the country. This is how he found out about the Italian treatment, and shortly after, about MTI.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 Neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

4 Pantoprazole infusions; Paracetamol.

2 sessions Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

8 nights Biophysical Treatment (5 hours each night while the patients are asleep + 45 minutes in the morning).
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at Verona airport, welcomed by his Patient Manager. Check in at Verona hotel. Light therapy and biophysical treatment at the room.

DAY 2: Rest day, in contact with his Patient Manager. Light therapy and biophysical treatment at the hotel room.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor and 1st infusions. Light therapy and biophysical treatment at the hotel room.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions. First session with physiotherapist. In the afternoon, visit of Soave castle with his Patient Manager. Light therapy and biophysical treatment at the hotel room.

DAY 5: Morning pick-up by his Patient Manager, 3rd infusions then day trip to Garda Lake with his patient manager. Light therapy and biophysical treatment at the hotel room.

DAY 6: Morning pick-up by his Patient Manager, 2nd visit with Rheumatologist Professor, last infusions and second physiotherapy session. The patient feels well, and he goes for a walk on his own in Verona center. Light therapy and biophysical treatment at the hotel room.

DAY 7: Day visit of Venice with the Patient Manager. Light therapy and biophysical treatment at the hotel room.

DAY 8: Rest day, in contact with his Patient Manager. Light therapy and biophysical treatment at the hotel room.

DAY 9: Pick-up from his Patient Manager, check out and drop off to Venice airport.

Follow up

MARCH 2023 (2 months after the Neridronate treatment): the patient does not report any improvement, but he feels positive about future outcomes, and he is exercising according to the therapist suggestions.

APRIL 2023 (3 months after the Neridronate treatment): the patient says that the pain is decreasing, and he can use his hand for much more activities, such as opening bottles, using a knife, dressing up, and he even is driving again.

JUNE 2023 (5 months after the Neridronate treatment): the patient is doing much better, his physiotherapist in USA got in touch with the one he met in Italy, and they are working together to help a faster recovery.

Conclusion

This case shows how important it is to have knowledgeable and cooperating medical providers. His American physiotherapist is the one who suggested the Neridronate as an option and kept following the patient after he was back home, in contact with the Italian colleague. They worked as a team to provide the patient a great support. The patient mentioned a general 60% improvement of symptoms, after 11 years of CRPS.

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.