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CRPS Treatment: pain in left hand for 11 years

General details and patient's info

Age:48 years old at the time of treatment.
Home Country:Australia.
Illness duration:11 years prior to the Neridronate Treatment.
Cause:Broken finger on left hand.
Symptoms:Burning pain; swelling (so much worse during flare ups); color changes to purple.
Clinical evaluation:CRPS. 
Time of treatment:March 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

This patient had heard about the Italian protocol with Neridronate on a CRPS support group, and then heard about us more specifically as well as the 360° treatment plan (highly recommended to longer CRPS cases) from a previous patient of ours, of whom the clinical case was very similar to his and had seen good results from the treatment. He contacted us shortly after to organize his trip to Italy. 

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Visits with Health Coach.
Visits with Nutritionist.

10 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

10 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions. Visit with Health Coach.

DAY 4: Morning pick-up by his Patient Manager, 2nd infusions.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd infusions. Visit with Nutritionist.

DAY 6: Rest day in the hotel, in contact with his Patient Manager.

DAY 7: Morning pick-up by his Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor. Visit with Health Coach.

DAY 8-10: The patient went to visit cities around Verona on his own for 3 days.

DAY 11: Pick-up by his Patient Manager, check-out, and drop-off at the Venice airport for his trip back home.

Follow up

MAY 2023 (2 months after Neridronate treatment): Patient refers to an improvement of the swelling of his hand. Pain levels are still pretty high, he says he might feel a slight difference.

AUGUST 2023 (5 months after Neridronate treatment): Patient refers having had a flare a month ago, and mentioned it was much less aggressive than he is used to and lasted much less too. He says his daily pain levels have dropped about 40%.

SEPTEMBER 2023 (6 months after Neridronate treatment): The patient confirms a total improvement of symptoms of 50%.


CRPS is unfortunately still considered a rare disease. It is hard for patients to find information on all available treatments worldwide. If taken years before, this patient would probably have had even higher percentages of improvements. However, as mentioned by the patient himself, living with the disease for 11 years, 50% improvement of all symptoms is “what I would consider a win!”.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.