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CRPS Treatment: pain in leg for 11 years

General details and patient's info

Age:57 years old at the time of treatment.
Home Country:Australia.
Illness duration:11 years prior to the Neridronate Treatment.
Cause:Foot surgery following a climbing incident.
Symptoms:Burning stabbing pain; leg turns purple (in particular with weather changes); pins and needles; swelling; extremely sensitive to season changes (weather changes); cannot bear weight on his right leg; cannot walk for more than a few minutes: uses a scooter or crutches to go around.
Clinical evaluation:CRPS diagnosis.
Time of treatment:February 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

Professional climber, this patient’s life was completely changed after his accident. The CRPS developed very fast after the surgery, after which he tried every treatment possible for the condition, however nothing seemed to provide lasting relief.
Googling treatments online, he found our website and started a year long research, after which he contacted us and finally came over in February 2022. 

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Pantoprazole infusions; Paracetamol.

3 sessions Massotherapy Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in the hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

8 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Verona airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion. The patient is still very tired from his trip and wishes to rest for the rest of the day.

DAY 4: Morning pick-up by his Patient Manager, 2nd Neridronate infusion.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion.

DAY 6: Rest day in the hotel, in contact with his Patient Manager. The patient feels some flu-like symptoms following the third infusion. After some Tylenol he says he feels better in the evening.

DAY 7: Morning pick-up by his Patient Manager, patient feels much better and does not refer to any side effects. 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion.

DAY 8: Rest day in the hotel, in contact with his Patient Manager.

DAY 9: Pick-up by his Patient Manager, check-out and drop-off at the Venice airport for his trip back home.

Follow up

APRIL 2022 (2 months after Neridronate treatment): the patient still refers to the same amount of pain but notices reduction in swelling and says his leg has not changed color yet in the last 2 months.

JUNE 2022 (4 months after Neridronate treatment): in the last months, the patient has witnessed a reduction in pain of about 20-30%. Swelling and color change are still not presenting in the leg.

NOVEMBER 2022 (9 months after Neridronate treatment): the patients refers a reduction in pain of 40-50%. He says he has managed to completely get off 3 of the pain medication he was taking daily which has drastically improved his stomach issues, connected to the number of medications taken daily.


Battling the condition for 11 years now, this patient had to take 7 daily medicines to help with the horrible pain, which had had a toll on his stomach over the years. Being able to lower this number to 4 medicines a day, he was able to control the issue they were creating on his stomach, as well as improving his daily pain of about 50%. Swelling and color change were no longer an issue, and weather changes did not provide excruciating pain as it used to before the treatment.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.