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CRPS Treatment: pain in leg for 2 months

General details and patient's info

Age:19 years old at the time of treatment.
Home Country:USA.
Illness duration:2 months prior to the Neridronate Treatment.
Cause:Tibia fracture.
Symptoms:Burning sensation; swelling; allodynia.
Clinical evaluation:CRPS. Extreme allodynia. /td>
Time of treatment:October 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient’s mom was looking at all possibilities of treatment for CRPS online, she found out about Neridronate and decided it was the best option for her son, given the short amount of time he had suffered from CRPS.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Pantoprazole infusions; Paracetamol.

3 sessions Massotherapy Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Daily Report

DAY 1: Arrival with is mother at the Venezia airport, greeted by his Patient Manager, followed by check-in at their Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions. Tourism in Verona.

DAY 4: Morning pick-up by his Patient Manager, 2nd infusions.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 6: DAY 7: Morning pick-up by his Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor. Tourism in Lake Garda.

DAY 7: Pick-up by his Patient Manager, check-out and drop-off at the Venice airport for their trip back home.

Follow up

JANUARY 2023 (3 months after Neridronate treatment): The patient is finally able to touch his leg without being in excruciating pain. He says his pain levels are lowering every week that passes.

APRIL 2023 (6 months after Neridronate treatment): Patients says he is in complete remission, the swelling and pain have completely disappeared.

AUGUST 2023 (10 months after Neridronate treatment): Patient confirms his remission and him and his mom are expressing gratitude for the program.


This patient was lucky to be able to get access to the treatment this quickly after the onset of his CRPS. This is why a concrete diagnosis is essential as soon as possible, in order to understand which treatment is most appropriate. This 18 years old boy now has a full life ahead, free of CRPS.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.