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CRPS Treatment: pain in right arm and hand for 2 years

General details and patient's info

Age:39 years old at the time of treatment.
Home Country:USA.
Illness duration:2 years prior to the Neridronate Treatment.
Cause:Surgery on his wrist.
Symptoms:Burning, stabbing pain; allodynia; abnormal hair growth; stiffness in the arm; loss of muscle strength.
Clinical evaluation:Complex Regional Pain Syndrome. 
Time of treatment:April 2021.

Why the Patient decided to undergo the CRPS Treatment in Italy

This patient had tried nerve block, spinal cord stimulator and Ketamine infusions before finally reading about Neridronate. He contacted us as soon as he found the company looking for a place giving the infusions, and arrived in Italy 4 months later.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions. Tourism in Verona.

DAY 3: Morning pick-up by his Patient Manager, 2nd infusions.

DAY 4: Rest day in the hotel, in contact with his Patient Manager.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd infusions. Patient feels some light side effect and is tired.

DAY 6: Morning pick-up by his Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor. Patient feels better, tourism in Soave.

DAY 7: Rest day in the hotel, in contact with his Patient Manager.

DAY 8: Pick-up by his Patient Manager, check-out, and drop-off at the Venice airport for his trip back home.

Follow up

JUNE 2021 (2 months after Neridronate treatment): the patient refers to his pain starting to lower, and the allodynia getting much better.

JULY 2021 (3 months after Neridronate treatment): the patient says his arm does not feel as “weak” as it used to be, and his pain levels have dropped some more.

OCTOBER 2021 (6 months after Neridronate treatment): The exercises taught by the physical therapist in Italy have helped the patient regain muscle strength in his arm, and he refers to the pain being down by 80%.


After fighting for 2 years with the condition, this patient finally found out about Neridronate. He was able to appreciate 80% in pain reduction, his allodynia has disappeared, and he regained muscle strength in his affected arm. It is important to understand that even if a patient is over a years or more in his battle with CRPS, there are still good chances of having lasting and life-changing improvements.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.