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CRPS Treatment: pain in right foot and leg for 6 months

General details and patient's info

Age:14 years old at the time of treatment.
Home Country:Costa Rica.
Illness duration:6 months prior to the Neridronate Treatment.
Cause:No specific trigger event, the young girl is a runner and she started feeling pain after a marathon.
Symptoms:Muscles spasms and cramps; high sensitivity, sensation of burning, needles, numbness; changes in color, impossible to put weight on the foot; pain level usually at 6 out of 10 with flares up at night.
Clinical evaluation:Complex Regional Pain Syndrome. 
Time of treatment:March 2024.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient underwent two sympathetic nerve blocks, pool therapy, physical therapy, mirror therapy, acupuncture. She also took different medications and supplements. She needed a wheelchair or crutches to walk. A family friend lives in Vicenza, close to our head office, and she visited us to receive all the information possible. The patient parents understood that, being that the girl had CRPS for very few months, she had great chance to get into remission and they immediately decided to travel to Italy.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:
2 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
9 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
9 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Verona airport, meeting with her Patient Manger, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Rest day in the hotel, in contact with her Patient Manager.

DAY 4: 1st visit with the Rheumatologist Professor and 1st infusions.

DAY 5: 2nd infusions.

DAY 6: 1st Rehabilitation session and 3rd infusions.

DAY 7: 2nd visit with Rheumatologist Professor.

DAY 8: 2nd Rehabilitation session and 4th infusions.

DAY 9: Rest day in the hotel, in contact with her Patient Manager.

DAY 10: Flight back home from Verona airport.

Follow up

APRIL 2024 (1 month after Neridronate treatment): the patient’s mother informs us that her daughter has reached remission of pain, sometimes the levels go to 1 out of 10, but most days she has no pain at all. She walks without any aid and has started to reduce her medications. She is now back to school.

MAY 2024 (2 months after Neridronate treatment): the patient’s mother says her daughter is in complete remission, she has 0 pain and is completely off any medication. She says the treatment was a blessing and her daughter is back to her normal self.


This young athlete is experiencing great and quick results from the Neridronate treatment. Due to his deep knowledge, the Rheumatologist Professor could prescribe the suitable medication dosage according to her age and weight, providing the best possible outcomes. Most Doctors are afraid of treating children, leaving them without answers and hope. We created a team of medical professionals that can plan a path for every patient, regardless of their age.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.