CRPS Treatment: pain in right foot and leg for 8 years

General details and patient's info

Gender:Female.
Age:49 years old at the time of treatment.
Home Country:Costa Rica.
Illness duration:8 years prior to the Neridronate Treatment.
Cause:Ankle fracture.
Symptoms:Endless burning on right foot up to the knee; stabbing pain she described at 8/10, very sensitive to touch. The pain increases after activities and at night, sleeping is hard. Shivering and feet cramps during the night. The patient needs a knee-scooter to go around when she is outside her house.
Clinical evaluation:CRPS. Allodynia and hyperesthesia.
Time of treatment:November 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient’s daughter is a nurse student. She did some research on CRPS, studied all available options, and she understood that Neridronate was the most promising one for her mom.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 Neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

4 Pantoprazole infusions; Paracetamol.

2 sessions Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

9 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

9 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at Verona airport accompanied by her daughter, meeting with the patient manager, check in at Verona hotel. Light therapy and biophysical treatment in hotel room.

DAY 2: Rest day, in touch with the patient manager. Light therapy and biophysical treatment in hotel room.

DAY 3: Pick-up by the patient manager, first visit with the Rheumatologist Professor, first rehabilitation session and first infusions. Light therapy and biophysical treatment in hotel room.

DAY 4: Pick-up by the patient manager, second infusions. In the afternoon, with the aid of the knee-scooter, visited Sirmione and Garda Lake. Light therapy and biophysical treatment in hotel room.

DAY 5: Pick-up by the patient manager, third infusions and second rehabilitation session. The patient feels a bit tired. Her daughter is impressed by the clinic and all the staff, whom she finds very attentive, knowledgeable and caring. Light therapy and biophysical treatment in hotel room.

DAY 6: Rest day. The patient feels better, she goes on a day trip to Padova with the patient manager. Light therapy and biophysical treatment in hotel room.

DAY 7: Pick-up by the patient manager, last visit with the Rheumatologist Professor and last infusions. Light therapy and biophysical treatment in hotel room.

DAY 8: Rest day, in contact with the patient manager. The woman is in a good mood and relaxed, having now completed the whole treatment. Light therapy and biophysical treatment in hotel room.

DAY 9: Pick-up by her patient manager, check out and drop-off Verona airport.

Follow up

DECEMBER 2022 (1 months after the Neridronate treatment): the patient says that she is feeling pain reduction specially in the morning. She is able to do more things, but at night the pain still is around 6 out of 10.

FEBRUARY 2023 (3 months after the Neridronate treatment): the patient says that she is having very good mornings, nearly pain free, always more painful at night but now about 5/10.

APRIL 2023 (5 months after the Neridronate treatment): the patient says that her pain has now also reduced at night, going to a 3-4 out of 10 and she can now sleep better. She can usually walk without aid, and she only uses the knee-scooter for long distances.

Conclusion

This is another successful story in which this patient has gone from a frequent 8/10 pain level to a 3-4/10.
Helping her sleep has helped her general mood as well as her daily strength and energy.

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.