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CRPS Treatment: pain in right foot for 1.5 years

General details and patient's info

Age:18 years old at the time of treatment.
Home Country:USA.
Illness duration:1.5 years prior to the Neridronate Treatment.
Cause:Motorbike accident in which she broke her foot on 3 different points.
Symptoms:Burning sensation going up the leg from the foot; all other symptoms are localized in the foot only however: skin sensitivity; redness; sensitive to weather change; sensitive to hot water; stress triggers flares-up; walking more than a few minutes triggers flares-up.
Clinical evaluation:Complex Regional Pain Syndrome. 
Time of treatment:November 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

This young girl had met another CRPS patient in a pain management program she went to, who was considering coming for treatment in Italy. Both families ended up organizing their arrival at the same period of time, so the girls go to meet again during their infusions at the clinic here in Italy.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions. Dinner with the team and the family of our other patient whom she had previously met.

DAY 5: Rest day in the hotel, in contact with her Patient Manager.

DAY 6: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 7: Morning pick-up by her Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Pick-up by her Patient Manager, check-out, and drop-off at the Venice airport for her trip back home.

Follow up

FEBRUARY 2023 (3 months after Neridronate treatment): The patient had referred improvements from the 2nd week after treatment already. Her pain levels had dropped drastically, and her flares-up were getting further and further away.

MAY 2023(6 months after Neridronate treatment): the patient has had amazing results from the treatment and confirms a complete remission of all symptoms.


Remission is the best-case scenario for CRPS patients undergoing the Neridronate infusions and the 360° treatment plan. Is has been seen in many patients, with permanent type of results, as the treatment does not have to be repeated. This case is one of the many lucky patients reaching remission, even after fighting the condition for a year and a half.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.