CRPS Treatment: pain in right hand and arm for 11 years

General details and patient's info

Gender:Female.
Age:35 years old at the time of treatment.
Home Country:USA.
Illness duration:11 years prior to the Neridronate Treatment.
Cause:Staphylococcus infection.
Symptoms:Searing, stabbing, shooting pain. Burning and freezing sensation. Sharp pain especially in the hand. Opening bottles and jars trigger horrific pain. The patient cannot write, type and lay on her right side. Occasionally pain and symptoms spread down to right leg and foot, making walking more than 5 minutes impossible.
Clinical evaluation:Complex Regional Pain Syndrome – which was diagnosed in 2022 only (9 years from the symptoms onset).
Time of treatment:June 2024.

Why the Patient decided to undergo the CRPS Treatment in Italy

Over the years, this patient took a lot of pain killers. After her diagnosis, she started physiotherapy, tried nerve blocks and Ketamine infusions which were then needed more and more frequently to keep the pain under control and brought heavy issues as hallucinations.
Her primary Doctor suggested to look for different treatments which is when she decided to travel to Italy.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 Neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

4 Pantoprazole infusions; Paracetamol.

3 sessions Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

7 nights Biophysical Treatment (5 hours each night while the patients are asleep + 45 minutes in the morning).
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at Venice airport greeted by her patient manager, check in at Verona hotel, briefing on the treatment week. Light therapy and biophysical treatment in hotel room.

DAY 2: Pick-up by her patient manager, blood tests, first visit with rheumatologist, first rehabilitation session, first infusions.

DAY 3: Pick-up by her patient manager, second infusions. The patient feels quite well, and she spends the afternoon visiting Verona with her patient manager. Light therapy and biophysical treatment in hotel room.

DAY 4: Pick-up by her patient manager, second rehabilitation session and third infusions. Light therapy and biophysical treatment in hotel room.

DAY 5: Rest day, in contact with his patient manager, she goes with her husband to Venice by train. Light therapy and biophysical treatment in hotel room.

DAY 6: Pick-up by her patient manager, second visit with the rheumatologist professor, third rehabilitation session, fourth infusions. After that she visits Garda Lake with the patient manager. Light therapy and biophysical treatment in his room

DAY 7: Rest day, in contact with his patient manager. Light therapy and biophysical treatment in hotel room.

DAY 8: Pick-up by his patient manager, check out and drop off Venice airport for the flight back home.

Follow up

JULY 2024(1-month post-treatment): the patient went back home very positive and determined to keep as active as possible. Her mother is personal trainer and helps her with the program planned in Italy by the physiotherapist.

AUGUST 2024 (2 months post-treatment): pain levels decreased to 3/4 on 10 (while it was 6/7 before the Neridronate), allowing her to finally to skip the Ketamine infusions. She reports that bad days happen much less often, and she can now work and do more activities.

Ongoing follow-up

Conclusion

When CRPS patients travel to Italy, they come with the hope of a decrease in pain and other symptoms, of course. Beside this, however, everyone has further personal goals: this young lady for example wanted to finally get free from pain killers that brought her many side effects.
2 months post-treatment, she reached that goal and is expected to see further improvements over the following months.

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.