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CRPS Treatment: pain in right hand for 18 years

General details and patient's info

Age:60 years old at the time of treatment.
Home Country:Australia.
Illness duration:18 years prior to the Neridronate Treatment.
Cause:Right wrist sprain.
Symptoms:Pain is limited to right hand and wrist and generally it is ranked at 8-9 on 10. The patient always wears a glove to protect from temperature, wind, water, human touch. The right hand is very weak, and the patient learned to do things with her left one.
Clinical evaluation:Complex Regional Pain Syndrome. 
Time of treatment:November 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

After 18 years of suffering and trying several options with very limited results (pain medication, acupuncture, physiotherapy, spinal cord stimulator, nerve block, psychologist) she got in touch on social media with a woman who had heard about the Neridronate treatment in Italy.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:
2 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
10 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
10 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Rest day in the hotel, in contact with her Patient Manager. The patient feels very tired and has jetlag issues.

DAY 4: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions. The patient is getting used to different time zone and she feels better.

DAY 5: Morning pick-up by her Patient Manager, 2nd infusions. The patient has a light fever, she takes some Tylenol to manage it.

DAY 6: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions. The patient still has some fever, she takes a long sleep in the afternoon which helps her.

DAY 7: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor, 4th infusions.

DAY 8: Rest day. In the afternoon the patient has a long walk in Verona.

DAY 9: Pick-up by her Patient Manager and day trip to Venice. The patient feels well, and she enjoys it.

DAY 10: Pick up from her Patient Manager and visit of Vicenza center.

Day 11: Early pick-up from her Patient Manager and drop off Venice airport to fly back home.

Follow up

FEBRUARY 2023 (3 months after Neridronate treatment): the patient says that the pain is still there, even though it has decreased a bit, but she now wears her glove only when she goes outside her home.

APRIL 2023 (5 months after Neridronate treatment): the patient says that her pain level is down to 4/5. This is helping a lot in doing more activities and leaving home more often, her mood is much better.

JULY 2023: The pain level settled on a 4 and the patient refers that her hand is stronger than before. She can write again with her right hand after years.

JANUARY 2024: (14 months after Neridronate treatment). The patient says that her pain levels are still around 4, which she can manage compared to her state prior to the treatment. Her mood is still positive, she keeps on doing regular exercise.


Neridronate treatment is much more effective early after the CRPS onset, sometimes even leading to a full remission. After many years, as in this case after 18 years, some improvements are to be expected anyway, and can bring strength, peace of mind, and a sense of normality to patients who have been suffering for this long.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.