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CRPS Treatment: pain in right leg for 2 years

General details and patient's info

Age:34 years old at the time of treatment.
Home Country:USA.
Illness duration:2 years prior to the Neridronate Treatment.
Cause:Patient was shot in the leg -he was a policeman.
Symptoms:Shooting pain; change of temperature; skin is red and shiny; abnormal hair growth, muscle weakness. Pain levels are described at 8/10, daily.
Clinical evaluation:CRPS. 
Time of treatment:March 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

This patient was a policeman and got shot on duty in 2021. It led to 3 different surgeries on his right leg. CRPS started after the 3rd surgery, and the gentleman was in pain for 11 months before a neurologist finally diagnosed him. He found out about Neridronate shortly after, and started organizing his treatment trip.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Clodronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by his Patient Manager, 2nd infusions.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 6: Rest day in the hotel, in contact with his Patient Manager.

DAY 7: Morning pick-up by his Patient Manager, 3rd Rehabilitation session, 4th infusions and 2nd visit with the Rheumatologist Professor.

DAY 8: Pick-up by his Patient Manager, check-out, and drop-off at the Venice airport for his trip back home.

Follow up

JUNE 2023 (3 months after Neridronate treatment): the patient reports very promising improvements on all symptoms, including pain levels, which he places at 5/10 daily.

SEPTEMBER 2023 (6 months after Neridronate treatment): the patient refers being in full remission of all symptoms. He is back to work now, and although he decided to be transferred in another unit in more of a bureaucratic picture, he is happy to be back in his environment.

MARCH 2024 (a year after Neridronate treatment): the patient is still in full remission and announces his wife’s pregnancy to us during our call!


Remission in a 2 years CRPS case is a very ideal outcome. This patient had been going to physical therapy since the original incident, which helped him a lot even post-treatment to regain his lost mobility.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.