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CRPS Treatment: pain in right leg for 7 years

General details and patient's info

Age:59 years old at the time of treatment.
Home Country:United States of America .
Illness duration:7 years prior to the Neridronate Treatment.
Cause:Bunion surgery .
Symptoms:Burning stabbing pain; foot swelling and occasionally it turns dark purple; pain goes from foot to hip, walking is possible with crutches, for short time, but climbing stairs is impossible.
Clinical evaluation:CRPS. 
Time of treatment:February 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient met a Radiologist Doctor to have an MRI. He was researching on Neridronate and suggested that, even though it is not a cure, he considered the Italian treatment the best option for a CRPS patient.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.
8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.
8 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Verona airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion. The patient is still very tired from his trip and wishes to sleep for the rest of the day.

DAY 4: Morning pick-up by his Patient Manager, 2nd Neridronate infusion. The Patient feels better, and he visits Verona center with the Patient Manager using a wheelchair.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion. The patient appreciates the differences respect to the first Rehabilitation session, he can move better and feels stronger.

DAY 6: Rest day in the hotel, in contact with his Patient Manager. The patient has some light flu-like symptoms and takes Tylenol as suggested to control them.

DAY 7: Morning pick-up by his Patient Manager, patient feels better and does not refer to any side effects anymore. 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion.

DAY 8: Day trip to Garda Lake and Sirmione with the Patient Manager, walking longer than expected.

DAY 9: Pick-up by his Patient Manager, check-out and drop-off at the Verona airport for his trip back home.

Follow up

APRIL 2022 (2 months after Neridronate treatment): The patient says that the foot pain remains at the same level, but he is motivated to exercise and keeping as active as possible.

JUNE 2022 (4 months after Neridronate treatment): so far, the patient rates the reduction of his pain from 30% to 40% depending on the days. He is walking without crutches more and more often.

JULY 2022 (6 months after Neridronate treatment): the patients refers to a reduction in pain of 40-50%. He is not taking any pain medications and does not use crutches at all. Climbing stairs is now possible but still quite hard, he keeps on exercising.

SEPTEMBER 2022 (8 months after Neridronate treatment): the patient says that he often has good days with pain levels at about 2. He may now climb stairs, which makes him very happy.


After 7 years of suffering with CRPS, the patient managed to improve his symptoms by about 50%, which allowed him to get rid of many medications, kept active and enroll in a gym which he attends multiple days a week.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.