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CRPS Treatment: pain in shoulder and leg for 5 years

General details and patient's info

Gender:Female.
Age:18 years old at the time of treatment.
Home Country:Canada.
Illness duration:5 years prior to the Neridronate Treatment.
Cause:2 right shoulder surgeries.
Symptoms:Stabbing pain in her right shoulder, temperature changes, swelling of her right hand, hand discoloration to purple. Limited movements of the shoulder. Burning pain in her left foot and leg, left foot swelling and discoloration.
Clinical evaluation:CRPS diagnosis. Grip strength reduced in her right hand; asymmetry of the shoulders, when she would reach up with both arms the left hand would reach higher than the right. Right scapula dyskinesia. Anxiety and depression.
Time of treatment:February 2020.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient tried 3 different treatments before, all lasting for several sessions, which did not help. She took pain medications which brought just very mild relief, that was never lasting.
The lady personally met a previous MTI patient that underwent Neridronate Treatment for CRPS and reported her good experience and outcomes.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
4 Pantoprazole infusions; Paracetamol.
2 sessions, 2 hours each, of Neuromuscular Rehabilitation Treatment with the Osteopath and Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

8 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at Venice airport, greeted by her Patient Manager and drive to the hotel in Vicenza. Check-in, briefing and rest. Light therapy and Biophysical treatment have been installed in her hotel room; her Patient Manager has explained all details on how to operate the machines.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st rehabilitation session and 1st Neridronate infusion. The patient is tired from the long flight to Italy and her veins are not very easy to find, however she is comfortable and peaceful. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. The patient feels tired and reports that she has mild muscle fatigue. In the afternoon they visit Vicenza. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 4: Morning pick-up by her Patient Manager, 3rd infusion. The patient feels tired and has bone ache. She is still in a good mood and is not worried about the discomfort. In the afternoon they walk around Vicenza. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 5: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor and last Neridronate infusion. The patient reports right shoulder and back pain. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 6: Morning pick-up by her Patient Manager, 2nd rehabilitation session: the patient performs all exercises and shows a wider range of mobility with reduced pain levels. In the afternoon they visit Verona’s city center, the girl is happy about touring and seeing Italy. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 7: Morning meeting with her Patient Manager and rest day. The patient is in a good mood but still feeling tired. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 8: Morning pick-up by her Patient Manager and day trip to Venice. The patient feels better, more rested and she has just mild achiness. She appreciates being able to visit Venice. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 9: Morning pick-up by her Patient Manager and drop off at the Venice airport for the flight back home. The patient feels better and is very positive.

Follow up

MAY 2020 (3 months after treatment): the patient experienced some improvements, has less pain and she is more positive and confident.

AUGUST 2020 (6 months after treatment): the young girl is doing much better, pain level decreased to minimum levels. She moves her shoulder and foot easily.

MAY 2021 (15 months after treatment): the patient is in remission; she recovered her full range of motion in her right shoulder. Right arm and left leg/foot pain disappeared. She may have some light pain when she works or walks too much but it does not last long and goes away with some rest. Her mood is positive, and she does not suffer from depression anymore.

Conclusion

This girl was suffering for over 5 years when she traveled to Italy and her life was hard, as a teenager, as she was affected by pain, depression and decreased mobility.
After the treatment, she is now in a lasing remission and recovered her full range of motion in her right shoulder.

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.