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CRPS Treatment: pain in ankle and leg for 6 years

General details and patient's info

Age:25 years old at the time of treatment.
Home Country:Costa Rica.
Illness duration:6 years prior to the Neridronate Treatment.
Cause:Ankle sprain, falling from the stairs.
Symptoms:Very sensitive to weather changes: when warm and moist she feels burning pain, when cold she feels pins and needles sensation. Walking more than a short distance brings severe pain with nausea, vomiting, breathlessness. Putting weight on the foot, or just keeping the foot on the floor for long periods of time, triggers swelling and redness. Leg feels icy. Other symptoms are chills, electric shocks, sharp pain, allodynia, hyperalgesia. Pain is generally at 8 or 9/10.
Clinical evaluation:CRPS diagnosis.
Time of treatment:February 2024.

Why the Patient decided to undergo the CRPS Treatment in Italy

The young patient tried several different medications as well as physiotherapy. She had two different spinal cord stimulators implanted: the first one was infected; the second one rejected and caused a spine infection. Like many CRPS warriors she studied other possible treatments online and she ended up considering Neridronate as her best option.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website:

4 Clodronate infusions, 4 Pantoprazole infusions; 4 Brain phosphatides + cyanocobalamin infusions ; 4 Hypothalamic phospholipids bolus doses ; Paracetamol.

3 sessions Massotherapy Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

9 days Light Therapy (in the hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

9 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Day trip with her Patient Manager to Maranello and the Ferrari Museum.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist, 1st infusion and 1st rehabilitation session. The patient is a bit tired and achy.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusion. The patient refers to some light flu-like symptoms but she is in a good mood, so she decides to have lunch with her patient manager and visit Verona center, with the aid of a wheelchair.

DAY 5: Morning pick-up by her Patient Manager, 3rd infusions, 2nd Rehabilitation session. The patient has a low fever in the morning, but she enjoys lunch with her Patient Manager in Sirmione (Garda Lake) and the visit to the small village.

DAY 6: Day trip to Venice with her Patient Manager. In the evening the patient feels tired but very happy.

DAY 7: Morning pick-up by her Patient Manager, 4th infusions, 2nd visit with Rheumatologist, 3rd rehabilitation session. The patient today feels better, no more side effects. She also recognizes her improvements during the rehabilitation work.

DAY 8: Rest day, always in contact with her Patient Manager.

DAY 9: Rest day, always in contact with her Patient Manager.

DAY 10: Pick-up by her Patient Manager, drop-off Venice airport to go back home. Today the patient feels much better, and she is very positive about her recovery during the next months.

Follow up

MARCH 2024 (1 month after treatment): the patient refers to the first improvements and the decrease of pain. She is very happy because she can drive the car a bit, which had been impossible for her in the last two years.


The patient discovered the Italian approach to CRPS 6 years after its onset. She regrets that during this long period she tried so many ineffective treatments and she wasted a long time in her recovery journey. This is why it is important for us to spread information on Neridronate treatment and point out that the earliest it is taken the better it is to allow its maximum results.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.