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CRPS Treatment: pain in ankle for 17 years

General details and patient's info

Age:30 years old at the time of treatment.
Home Country:United States of America.
Illness duration:17 years prior to the Neridronate Treatment.
Cause:Left ankle injury.
Symptoms:Numbness, tingling, burning, stinging pain. Sensitivity to touch, spasms in both feet. Pain in her hips, migraines, balance loss, hot flashes, light headedness, lower back pain. Triggers: walking, stress, riding in a car, standing. Cannot walk, stand, jump, sit with her legs hanging, sit in a bathtub.
Clinical evaluation:CRPS diagnosis. Severe acute onset of pain in feet and legs. Degenerative disc disease of lumbar spine. Patient is in a wheelchair.
Time of treatment:February 2021.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient was diagnosed with CRPS 17 years prior to the treatment. She cannot walk nor do any of the daily activities she used to. She tried a couple of medications that did not help. She did not want to try invasive procedures, so when she discovered that the Neridronate treatment is available in Italy, she decided that this could be the best option for her to get better.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website:
4 Pantoprazole infusions; Paracetamol.

2 sessions Neuromuscular Rehabilitation Treatment with the Physiotherapist and Osteopath.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Vicenza. Briefing focused on next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 3: Morning pick-up by her Patient Manager, and 2nd Neridronate infusion. The patient has some bone ache in her legs and body.

DAY 4: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. The patient feels flu-like symptoms. But all is kept under control with some Tylenol.

DAY 5: Morning pick-up by her Patient Manager and 3rd Neridronate infusion.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, 2nd Rehabilitation session and last Neridronate infusion.

DAY 7: Morning pick-up by her Patient Manager, and day trip to Venice for tourism. She needed the wheelchair.

DAY 8: Morning pick-up by her Patient Manager and drop-off at the Venice airport.

Follow up

MAY 2022 (2 months after the Neridronate treatment): the patient feels better, and she had small improvements.

DECEMBER 2022 (10 months after the Neridronate treatment): the patient had further improvements and she does not need the wheelchair anymore.


This lady has a long history of CRPS, she has been suffering from 17 years. She is the mother of 2 children and life was very hard for her. After the Neridronate infusions she experience some up and downs. She is very happy about the results, she can now move, walk, she lost weight, she does not need the wheelchair or the crutches anymore. She may have some bad days with pain flaring up, but they last a short time, and she can perform her daily activities.
Many people suffer from CRPS for a very long time, for some of them it is harder to reach complete remission, but any pain and symptoms decrease can make a huge difference in their lives.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.