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CRPS Treatment: pain in arm and hand for 2 years

General details and patient's info

Age:19 years old at the time of treatment.
Home Country:Australia.
Illness duration:2 years prior to the Neridronate Treatment.
Cause:Broken finger.
Symptoms:Burning pain; stiffness in the arm; high sensitivity to touch; weather changes affect the level of pain; color changes.
Clinical evaluation:CRPS diagnosis.
Time of treatment:November 2020.

Why the Patient decided to undergo the CRPS Treatment in Italy

In the patient’s city, another person suffered from CRPS (which she often calls “fate” as it is a very small city and a very rare disease). This person went to Italy 2 years prior and had seen very good results. The patient’s mother then contacted us shortly after she had talked to the previous patient of ours. 

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days. The patient’s mother absolutely loved the hotel.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. Tourism in Verona.

DAY 4: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion. Touring of Verona.

DAY 5: Rest day in the hotel, in contact with her Patient Manager.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion. Tourism in Vicenza.

DAY 7: Tourism in Venice all day, with gondola ride.

DAY 8: Rest day in the hotel, in contact with her Patient Manager.

DAY 9: Pick-up by her Patient Manager, check-out and drop-off at the Venice airport for her trip back home.

Follow up

DECEMBER 2020 (1 month after Neridronate treatment): The patient feels her muscles’ strength has gotten better.

MARCH 2021 (4 months after Neridronate treatment): Patient reports her pain is completely gone. She says she feels like she “can do anything I want now”. Her mom says her mood has improved a lot and she seems much happier and hopeful.

JULY 2021 (8 months after Neridronate treatment): The patient’s mom calls us and informs us the full remission of her daughter, who is currently on holidays in Dubai! She says the treatment has “changed my daughter’s life” and she does not report any symptoms whatsoever.


These are brilliant results from the treatment. The patient was young and energetic, she followed her rehabilitation program to the letter, and was able to witness an amazing recovery into full remission. Her remission is lasting to this day, and we could not be happier for her.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.