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CRPS Treatment: pain in arm and hand for 4 months

General details and patient's info

Age:21 years old at the time of treatment.
Home Country:New Zealand.
Illness duration:4 months prior to the Neridronate Treatment.
Cause:Broke his middle finger.
Symptoms:Pain is stronger in the hand but goes up the arm. Changes in color and temperature. Burning sensation, pins and needles sensation.
Clinical evaluation:CRPS diagnosis. Allodynia and hyperalgesia. Patient presents exhaustion signs.
Time of treatment:December 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient is a Medicine Student, he found out about Neridronate on a hospital CRPS forum online. He did some research and found the original study papers. He quickly figured out it was the best option for him, especially being diagnosed this recently.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website:

4 Pantoprazole infusions; Paracetamol.

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 4: Morning pick-up by his Patient Manager, 2nd Neridronate infusion. Touring in Lake Garda.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion.

DAY 6: Rest morning in the hotel, in contact with his Patient Manager. In the afternoon the patient goes to Verona on his own to discover the town.

DAY 7: Morning pick-up by his Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion.

DAY 8: Morning pick-up by his Patient Manager, check-out Verona Hotel and check in Venice hotel. Touring of Venise.

DAY 9: Pick-up by his Patient Manager, check-out and drop-off at the Venise airport for his trip back home.

Follow up

JANUARY 2023 (1 month after Neridronate treatment): patient says he can feel some changes in his arms but “cannot exactly describe what and how”. He is following the exercise plan given by the physiotherapist in Italy.

MARCH 2023 (3 months after Neridronate treatment): the pain and burning sensation about nearly gone, only during flare ups he feels the burn in his arm.

AUGUST 2023 (8 months after treatment): Patient reports a full remission. All symptoms and pain levels are now down to 0.

JANUARY 2024 (1 year after treatment): The young man is thriving, still studying medicine, he is in a long-lasting remission and has gotten all his energy back. He said he is still going through with his physio exercises as he thinks it helps him a lot with general mobility.


This patient was lucky to hear about and be able to access the treatment this quickly after the onset of his CRPS, which allowed him to go into full remission.
Neridronate is definitely the best choice of treatment for CRPS warriors, and for cases such as this patient’s, it can lead to a full remission of all symptoms.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.