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CRPS Treatment: pain in both arms for 9 years

General details and patient's info

Age:35 years old at the time of treatment.
Home Country:USA.
Illness duration:9 years prior to the Neridronate Treatment.
Symptoms:Tingling sensation; Burning pain; unable to hold objects with her right hand; swollen hands; change of color and hair growth on the arms.
Clinical evaluation:CRPS diagnosis. The patient is sleep deprived as she cannot sleep at night because of the pain.
Time of treatment:May 2020.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient had tried so many treatments. From Ketamine infusions to spinal cord stimulator, rehabilitation therapy, mirror therapy, sensorial therapy, acupuncture, and more.
Most of them did not help, and the ones that did only lasted for short periods of time. She found out about MTI online and decided to give a shot to the Neridronate infusions. 

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website:

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 4: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. Touring of Verona.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion.

DAY 6: Rest day in the hotel, in contact with her Patient Manager.

DAY 7: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion. The physiotherapy session was very emotional, the patient, with the help of our specialist, saw herself doing movements she hadn’t’ been able to do for years.

DAY 8: Pick-up by her Patient Manager, check-out and drop-off at the Venice airport for her trip back home.

Follow up

JULY 2020 (2 months after Neridronate treatment): the patient is doing well; she is continuing her physiotherapy exercise plan.

SEPTEMBER 2020 (4 months after Neridronate treatment): the patient happily reports she can hold cups in her right hands! Pain levels have decreased, she is exercising.

DECEMBER 2020 (6 months after Neridronate treatment): the patient is happy with her results: she can now hold objects with her right hand and reports a lowering of pain levels from 90% daily, to 30%.


In long cases such as this one, the multidisciplinary approach is essential to hope for the best outcomes. It is important that the patient follows exercises and diet plans too, in order to help the treatment give its best. This patient reports a pain reduction of 60%.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.