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CRPS Treatment: pain in both hands for 5 years

General details and patient's info

Age:40 years old at the time of treatment.
Home Country:USA.
Illness duration:5 years prior to the Neridronate Treatment.
Cause:Right wrist fracture while playing basketball.
Symptoms:Symptoms started in wright hand and after a couple of years they mirrored to the left one. Burning pain; electric sensation; very sensitive to touch. Picking things up is very hard, as well as writing, typing and, generally, doing anything requiring the use of the hands.
Clinical evaluation:CRPS. 
Time of treatment:February 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient, a former professional basketball player, broke her wright wrist during a game with friends. The trauma left her with an unbearable pain in her hands, she was diagnosed with CRPS a year after. She followed physical therapy sessions and was under a lots of pain medicine: even though they helped a bit with the pain, she just could not use her hands anymore. She was in need of help for all her daily tasks. Her trainer is the one who found out about MTI and the Neridronate treatment and convinced her to travel to Italy.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

3 sessions Neuromuscular Rehabilitation Treatment Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

8 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Vicenza. Briefing focused on the next days.

DAY 2: Rest day, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions. The patient feels a bit tired, but she is happy to start the treatment.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions. The patient feels better than yesterday, she has lunch in Verona with her Patient Manager, and they spend the afternoon having a long walk in the city center.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions. The patient has some light flu-symptoms, but she still works very well with the Physiotherapist.

DAY 6: Rest day, in contact with her Patient Manager. In the afternoon she takes a walk in Vicenza center.

DAY 7: Morning pick-up by her Patient Manager, 4th infusions and 2nd visit with the Rheumatologist Professor. The flu symptoms are gone, and she feels quite well.

DAY 8: Day trip to Venice with her Patient Manager.

DAY 9: Early pick-up by her Patient Manager, check-out, and drop-off at the Venice airport for her trip back home.

Follow up

APRIL 2022 (2 months after Neridronate treatment): the patient is very thorough on following the exercises suggested by the Physiotherapist during her treatment week. She still feels pain but notices that it is changing, and that the electric sensation is decreasing.

JULY 2022(4 months after Neridronate treatment): the patient refers to a general improvement of the symptoms. At this point, she could now write, type, and use her hands (the left one more than the right one).

OCTOBER 2022 (8 months after Neridronate treatment): the patient says her pain has become much more bearable and she manages it easily. She can now perform all her daily activities without being helped.

FEBRUARY 2023 (one year after Neridronate treatment): the patient says that she has had only a few bad days, in which she needed pain killers, but generally she is well. She plans to wait a bit longer before trying playing basketball again.


The patient fully reached her primary goal: using her hands for all her activities and becoming totally independent from her caregivers. CRPS is not only a matter of pain but also of everyday life.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.