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CRPS Treatment: pain in both legs and shoulder for 26 years

General details and patient's info

Age:61 years old at the time of treatment.
Home Country:United States of America.
Illness duration:26 years prior to the Neridronate Treatment.
Cause:Fracture left fibula.
Symptoms:Sharp, dull pain from 8/10 to 10/10. Swelling. Change in skin color. During a flare up, she cannot move her arm. Need a walker or a wheelchair as she cannot walk.
Clinical evaluation:CRPS diagnosis.
Time of treatment:November 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

Her husband talked to another patient who came to Italy to undergo the treatment with MTI, and after doing some further research, she decided it was time for her to try the treatment too.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website:

4 Clodronate infusions (300mg, IV in saline Solution 0,9% 250 ml)
4 Ketorolac infusions (10mg i.v. in saline Solution 0.9% 100ml)
4 Ademetionine infusions (400mg i.v. in saline Solution 0.9% 100ml)
4 Hypothalamic phospholipids infusions (12ml in bolus dose)
4 Pantoprazole infusions (40mg i.v. in saline Solution 0.9% 100ml)

2 sessions, 30min each, of Neuromuscular Rehabilitation Treatment with the Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

1 visit with Health Coach with Dexa Scan

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her first Hotel in Verona. Briefing focused on the next days.

DAY 2 and 3: Rest days, in contact with her Patient Manager.

DAY 4: Morning pick-up by her Patient Manager, Blood tests, 1st Rehabilitation session, and 1st infusions.

DAY 5: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 2nd infusions.

DAY 6: Morning pick-up by her Patient Manager, 3rd infusions, 2nd Rehabilitation session.

DAY 7: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor, last infusions, visit with Health Coach and Dexa Scan.

DAY 8: Tourism in Venezia with Gondola ride.

DAY 9-10: Rest days, in contact with her Patient Manager.

DAY 11: Morning pick-up by her Patient Manager, drop-off Venice airport to go back home.

Follow up

JANUARY 2024: the patient is following the exercise plan given by the physiotherapist during her treatment week. She says she can walk a little more each day and reports she hasn’t needed to use a wheelchair, feels stronger and more stable.

FEBRUARY 2024: the patient says her pain levels have decreased and she is now walking without any kind of aid.


This case is an outstanding case. This patient suffered from CRPS for the last 26 years and could not move around without a wheelchair or a walker. Only 2 months after her treatment, this patient happily reports she can now walk without any type of aid, and her pain levels have decreased. She also mentioned feeling more stable and stronger. The full effect of the treatment can be appreciated within the 6 months following the treatment, which means she most probably will see even further improvements of her condition.
Siding the Neridronate infusions with Clodronate enhanced the initial effect of the drug and contrasted its side effects. Experiencing both side therapies (Light and Biophysical) helped with her level of inflammation and with repairing the affected areas from within. And the Health Coach and Neuro-muscular sessions with tailor-made reports helped her continue the healing process once going back home.
This shows that attacking the disease from all possible sides in a multidisciplinary approach is definitely the right path for CRPS patients.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.