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CRPS Treatment: pain in both legs and shoulder for 6 months

General details and patient's info

Age:37 years old at the time of treatment.
Home Country:United Kingdom.
Illness duration:6 months prior to the Neridronate Treatment.
Cause:Car accident.
Symptoms:Intense pain, often 10/10. Pain gets worse with standing, walking, exercising. Sometimes making it hard to wear shoes. Left elbow and shoulder also show pain, upper limbs movements are possible but generate discomfort.
Clinical evaluation:Clinical diagnosis for bilateral lower limbs Complex Regional Pain Syndrome. Suspected CRPS of upper left limb too.
Time of treatment:December 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient, a young lawyer, developed CRPS after a car crash. He was diagnosed with CRPS in his feet about 3 months later and he was treated with 3 different medications. Doctors in United Kingdom were taking into consideration a shoulder surgery, as the pain started to arrive there too. He felt that it was not the right path for him and researched on further options: he decided that Neridronate was the most promising and travelled to Italy as soon as he could.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Pantoprazole infusions; Paracetamol.

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day, in contact with his Patient Manager. The patient and his mother visited Verona center.

DAY 3: Morning pick-up by his Patient Manager, blood tests, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 4: Morning pick-up by his Patient Manager, 2nd Neridronate infusion, the patient feels tired and sleeps during the treatment; in the afternoon, lunch in Verona center and short walk with his Patient Manager.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion. He feels tired and has some flu-like symptoms, so he decides to cancel the Garda Lake tour to be able to rest and recover.

DAY 6: the patient is still very tired and does not feel well, he has a light fever (same as his mother). He prefers to cancel the planned day trip to Venice and rest in his hotel. His Patient Manager keeps in touch during the day, caring for his condition.

DAY 7: Morning pick-up by his Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion. The patient also meets the Health Coach after undergoing the Dexa Scan: the coach analyzes his case as well as the scan results and prepare a nutrition and exercise program to be started once back home.

DAY 8: Pick-up by his Patient Manager and drop-off at Verona airport.

Follow up

DECEMBER 2023 (1 week after Neridronate treatment): once back home the patient discovered that he had Covid, which temporarily increased his pain and tiredness. This situation affected his mood and he felt quite discouraged.

JANUARY 2024 (1 month after Neridronate treatment): the patient feels much better, and he mentions that, after Covid was over, he started to experience improvements and felt much more confident. He is paying attention to his nutrition, taking Vitamin D supplements, which is very important to boost the Neridronate effect, and exercising on a regular basis.

FEBRUARY 2024 (2 months after treatment): The patient says that his feet and legs feel much better and that he is still experiencing some pain in his left shoulder. He recognizes that Neridronate is working, and he has positive expectations for the next months’ improvements.


This patient felt the first improvements within the few weeks after the infusions and is likely to have further results shortly. His legs feel much better. Undergoing the treatment at the disease’s earliest stage, as this patient did, gives the highest chance of pain reduction, great recovery and, often, remission.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.