Download our free ebook: your guide to CRPS filled with incredible knowledge on the condition

CRPS Treatment: pain in both legs for 3 years

General details and patient's info

Age:71 years old at the time of treatment.
Home Country:United States of America.
Illness duration:3 years prior to the Neridronate Treatment.
Cause:Left ankle fracture.
Symptoms:Constant burning pain, hypersensitivity to touch. Discoloration, sharp electric pain. Swelling. Unable to sleep due to the pain; Standing, climbing stairs and walking is only possible for a short period of time.
Clinical evaluation:Complex Regional Pain Syndrome 1 of left lower leg. The patient presented an antalgic gait. During light touch of left lower extremity, classic allodynia is noticeable. Balance is within functional limits.
Time of treatment:November 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient, a lively lady formerly very active, tried several options to treat her condition: plenty different medications, shoe arch support, lumbar sympathetic block; she also underwent surgical procedures such as cervical fusion, lumbar fusion, rhizotomy, hip replacement. They just brought none or minimal results. The patient’s husband being Italo American, he managed to easily get information on the Italian approach to CRPS, after which they decided to travel here to undergo the Neridronate protocol.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website:

4 Pantoprazole infusions; Paracetamol.

3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

10 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

10 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Verona train station, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion, visit of Verona center. The patient feels generally well, she just reports a “different” kind of pain in her leg.

DAY 4: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion, the patient is feeling well. She cooperates with the Physiotherapist doing all the suggested exercises. During the afternoon the patient and her husband visit Garda Lake and enjoy lunch with their Patient Manager.

DAY 5: Rest day, in contact with her Patient Manager. The patient and her husband visit Verona’s city center on their own.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, last Neridronate infusion and 3rd Rehabilitation session. The patient appreciates the Physiotherapy specialist, who is careful to treat her in a smooth way and offers various suggestions to manage her activities when going back home.

DAY 7: Rest day, in contact with her Patient Manager. The patient feels quite well and with her husband went to Trento by train.

DAY 8: Rest day, in contact with her Patient Manager. The patient feels well and since she enjoyed Trento the previous day, they decided to go back there again.

DAY 9: Rest day, in contact with her Patient Manager. Today the patient reported a higher pain level in her left leg, so she decided to get some more rest and just have a short visit of Verona center.

DAY 10: Morning pick-up by her Patient Manager and drop-off at Verona train station.

Follow up

DECEMBER 2023 (1 month after Neridronate treatment): the patient feels that the treatment is starting to work, experiencing small differences in her pain. She is positive and optimistic for further results.

JANUARY 2024 (3 months after Neridronate treatment): the patient had a bad flu at the end of December which unfortunately caused a flare-up in the leg too, with swelling and burning. After that episode, however, she felt much better: she kept active and kept on exercising. She said that she could finally shave her legs again, with no pain, for the first time in years. She is also focusing on her nutrition as she understands the importance of an anti-inflammatory diet.


The patient has seen good initial improvements, only 2 months after her treatment. The side therapies (light treatment, biophysical treatment, rehabilitation) advised to the patient as a booster for Neridronate were essential in her case. We will keep in touch with the patients to monitor all further improvements.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.