Download our free ebook: your guide to CRPS filled with incredible knowledge on the condition

CRPS Treatment: pain in both legs for 4 years

General details and patient's info

Age:43 years old at the time of treatment.
Home Country:United States of America.
Illness duration:4 years prior to the Neridronate Treatment.
Cause:Car accident, followed by a lot of surgeries on both legs.
Symptoms:Pain started in left foot and spread to the leg after the first of 5 surgeries. After the 3rd surgery, CRPS spread in both legs. Limited range of motion, walks with the help of a cane. Burning sensation in both legs. Swelling. Stress provokes flare ups.
Clinical evaluation:CRPS diagnosis. Very important swelling, especially on left leg. Patient is in very high level of pain.
Time of treatment:March 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

After 5 different surgeries and the spread of her CRPS, this patient started to look for different treatment options which wouldn’t involved “being cut open again” – in her own words. She tried physiotherapy and mirror therapy but without any improvements. She found out about Neridronate during one of her research sessions and contacted us right away.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website:

2 sessions, 30min each, of Neuromuscular Rehabilitation Treatment with the Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

8 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion. Touring of Verona with Patient Manager.

DAY 4: Morning pick-up by her Patient Manager, 2nd Neridronate infusion.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion.

DAY 6: Rest day in the hotel, in contact with her Patient Manager. Dinner in Soave with Patient Manager for special event at the Castle.

DAY 7: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion.

DAY 8: Rest day in the hotel, in contact with her Patient Manager.

DAY 9: Pick-up by her Patient Manager, check-out and drop-off at the Venise airport for her trip back home.

Follow up

JUNE 2019 (3 months after Neridronate treatment): patient reports a 20% reduction of pain, and 40% improvement of her range of motion.

DECEMBER 2019 (9 months after Neridronate treatment): the patient reports no more swelling of right leg, and an 80% improvement of swelling of left leg. Pain levels are now at a constant 4/10 instead of the 10/10 she reported during her first visit with the rheumatologist in Italy.


This patient had pretty good results from the treatment and felt an improvement on her day-to-day life.
Her pain levels are now at 4/10 instead of the 10/10 she originally was at daily.
She did not manage to find a physiotherapist who could help her further when she came back home. The exercise program given by our specialist helped the patient, but we always strongly recommend finding a good medical support team when getting back home, including a physiotherapist specialized in chronic pain.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.