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CRPS Treatment: pain in foot and ankle for 5 months

General details and patient's info

 

Gender:Female.
Age:17 years old at the time of treatment.
Home Country:USA.
Illness duration:5 months prior to the Neridronate Treatment.
Cause:Foot injury.
Symptoms:Extreme sensitivity in her toes and foot, she sometimes experienced temperature changes in foot and ankle; suffered from a mix of throbbing, sharp, piercing pain. Toes were unable to move, she needed a specific boot to walk.
Clinical evaluation:CRPS diagnosis. Algoneurodistrophy in her left ankle and foot.
Time of treatment:February 2022.

Why the Patient decided to undergo the CRPS Treatment in Italy

This young girl is a cheerleader and CRPS has affected all her activities. Due to the pain, she was not able to practice most of them anymore. She was quickly diagnosed and tried 5 different treatments such as pain medications and localized creams, but she did not see appreciable results. Her parents searched online and found information and positive stories on the Neridronate treatment, so they decided to travel to Italy, the only country having approved this protocol.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
4 Pantoprazole infusions; Paracetamol.

2 sessions, 2 hours each, of Neuromuscular Rehabilitation Treatment with the Osteopath and Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

6 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

6 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her first Hotel in Venice. Briefing focused on next days.

DAY 2: Touristic morning in Venice with her Patient Manager. Later in the afternoon, check-in at her second hotel in Vicenza. The patient feels well, she was excited about her first day in Venice and is looking forward to being treated. Light therapy and Biophysical treatment have been installed in her hotel room; her Patient Manager has explained all details on how to operate the machines.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st rehabilitation session and 1st Neridronate infusion. The patient is well, she just feels a bit tired. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 4: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. Touristic tour in Verona center. The patient has light chest pain, probably due to the rehabilitation and breathing exercises. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 5: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. Touristic tour in Verona center. The patient has mild bone ache and feels tired. The Rheumatologist Professor prescribes some cortisone to help with these light side effects. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, 2nd rehabilitation session, last Neridronate infusion. The patient feels well, she is a bit tired and needs some rest. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 7: Pick-up by her Patient Manager and touristic afternoon in Vicenza followed by some well-deserved rest. She then proceeds with Light therapy and Biophysical treatment in her hotel room.

DAY 8: Morning pick-up by her Patient Manager, hotel check-out and drop-off at Venice airport to fly back home.

Follow up

JULY 2022 (6 months post treatment): the patient is nearly totally pain free with just some minor short-lasting flare up. She is back to all her activities, including cheerleading, surfing, running, and now manages to walk normally.

DECEMBER 2022 (10 months post treatment): the patient says to be in full remission of all symptoms.

Conclusion

This case is a very successful one as it led to a total remission of the patient’s CRPS symptoms. This is more likely to happen when the Neridronate infusions are administrated at the early stages of the disease: the best results can be expected if taken within 6-9 months.

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.