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CRPS Treatment: pain in foot and leg for 2 years

General details and patient's info

Gender:Female.
Age:39 years old at the time of treatment.
Home Country:United States of America.
Illness duration:28 months prior to the Neridronate Treatment.
Cause:Neuroma removal surgery.
Symptoms:Cold, burning, stinging ache, pins and needles. Main triggers are stress, lack of sleep, wearing shoes, being active, a mild breeze, vibrations of any kind, standing. Sometimes hurts with no reason. Ankle is weak and hard to move, cramping in foot.
Clinical evaluation:CRPS diagnosis. Pain in right foot, difficulty walking, stump neuroma right 3rd IS, change in color of the extremity, cool to touch, increased sensation and burning with light touch, barely able to tolerate touch. Capillary filling.
Time of treatment:August 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient ‘s Doctor sent her to Bisphosphonates trial in USA but she was given the placebo. The same Doctor suggested her to travel to Italy because he considered Neridronate to be the best option to treat CRPS.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
4 Pantoprazole infusions; Paracetamol;

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Vicenza. Briefing focused on next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, visit of Verona’s city center.

DAY 3: Morning pick-up by her Patient Manager, 1st Neridronate infusion, the patient feels tired, and she sleeps during the infusion. Visit of Vicenza.

DAY 4: Morning pick-up by her Patient Manager and 2nd Neridronate infusion. The patient feels tired and achy, she sleeps during infusion. Visit of Soave.

DAY 5: Morning pick-up by her Patient Manager and 3rd Neridronate infusion. The patient feels tired but agrees to visit Padova.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, last Neridronate infusion. The patient feels better than in the previous days.

DAY 7: Morning pick-up by her Patient Manager, drop-off Vicenza train station.

Follow up

SEPTEMBER 2019 (1 month after Neridronate treatment): the patient feels a good general improvement of her condition.

OCTOBER 20219: (2 months after Neridronate treatment): the patient is pain free and back to most activities, including horse riding.

APRIL 2020 (6 months after Neridronate treatment): the patients refers important progress and improvements, no more pain, walking again and enjoying her life.

APRIL 2022: (30 months after Neridronate treatment): the patient reports to feel nearly 100% better, she just feels some pain from time to time.

AUGUST 2022 (3 years after Neridronate treatment): the patient is in remission with just occasional bad days.

AUGUST 2023 (4 years after Neridronate treatment): the patient is doing amazing. She only has mild flares occasionally: she ranges their pain level at 3 and says they last 1 to 3 days. They are even getting less and less frequent. Months before our conversation, she had sprained her CRPS ankle and she was afraid that the disease would spread again: on the contrary, she and her Doctor were surprised to see a quick healing and remission.

Conclusion

This patient is in a long lasting remission, with very rare flare-ups she describes as 3/10 pain level-wise.
3 years after the treatment she sprained her ankle and was terrified of seeing the CRPS coming back, but being stronger with Neridronate, it did not happen !

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.