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CRPS Treatment: pain in foot and leg for 2 years

General details and patient's info

Age:32 years old at the time of treatment.
Home Country:New Zealand.
Illness duration:2 years prior to the first Neridronate Treatment.
Cause:Multiple fractures falling.
Symptoms:Strong burning pain in toes and ankle. Stabbing pain and color changes purple/red. Swelling and seating. Pain gets worst and worst which has started emotional issues. Stress triggers flare up. Cannot stand nor walk. Patient can use only her left side. Movements are also limited on her right hand and arm, with pins and needles sensation.
Clinical evaluation:CRPS diagnosis with radiation of muscle spasm and pain from right ankle region to right leg and right side of body, right arm & shoulder and right side of neck. She also underwent several treatments and finally her Doctor in New Zealand referred her to Italy to have the Neridronate infusions.
Time of treatment:October 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient could not walk nor stand for over 2 years. She has 4 children she could not take care of. She was taking lots of medication, with nearly no results and started developing emotional issues.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
2 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist and Osteopath.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Milan airport, greeted by her Patient Manager, followed by check-in at her Hotel in Vicenza. Briefing focused on next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion. The patient is very emotional, and she cries. She appreciates the Rehabilitation session a lot.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. The patient feels very tired, and, in the evening, she has some side effects, nausea.

DAY 4: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. The patients feels better and in the afternoon, she agrees to visit Vicenza.

DAY 5: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor and last Neridronate infusion.

DAY 6: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and then visit of Venice with gondola ride. The patient is glad because, after more than 2 years, she can lay her foot on the floor.

DAY 7: Morning pick-up by her Patient Manager and visit of Vicenza center.

DAY 8: Morning pick-up by her Patient Manager and day trip to Venice.

DAY 9: Morning pick-up by her Patient Manager and Circus show.

DAY 10: Morning pick-up by her Patient Manager and drop-off at Padova train station.

Follow up

JANUARY 2020 (3 months after Neridronate treatment): the patient feels better and she had small improvements.

OCTOBER 2020 (12 months after Neridronate treatment): the patient had further improvements, she can walk again, and her goal is to go back to her sport activities.


This patient had great improvements, she can now walk again after spending two years moving around with a knee scooter.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.