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CRPS Treatment: pain in foot and leg for 4 months

General details and patient's info

Age:12 years old at the time of treatment.
Home Country:United Kingdom.
Illness duration:4 months prior to the Neridronate Treatment.
Cause:Right foot injury (shut in car door).
Symptoms:Intense stabbing pain, burning sensation, hypersensitivity from foot to knee: cannot bear clothes. Walking only with crutches, bearing weight on it is impossible.
Clinical evaluation:CRPS diagnosis. On examination extremely distressed, finding difficult to sit still. Able to take some weight through his right foot when using crunches. Very reluctant to allow even light touch. Crimson appearance of the skin of right foot and ankle, no swelling.
Time of treatment:July 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient’s mother looked for information online about any available options to treat her son; even though he was quickly diagnosed, in his country he could not find help: he was sent from one hospital to another, failing to provide treatment suggestions, other than pain medicine and psychological support.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

1 session, 2 hours, of Neuromuscular Rehabilitation Treatment with the Osteopath and Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by his Patient Manager, and check-in at the hotel in Vicenza.

DAY 2: Morning pick-up by his Patient Manager, 1st visit with Rheumatologist Professor, 1st Neridronate infusion.

DAY 3: Morning pick-up by his Patient Manager, 2nd Neridronate infusion. The patient feels muscles pain and cries a lot: he is too nervous and does not agree to his first physiotherapy session. To help him, the Rheumatologist Professor prescribes some Paracetamol.

DAY 4: Morning pick-up by his Patient Manager, 2nd visit with the Rheumatologist Professor and 3rd Neridronate infusion. The patient is still experiencing muscle pain and joint stiffness, but he feels better than the previous day.

DAY 5: Morning pick-up by his Patient Manager, last Neridronate infusion. The patient feels much better, all side effects improved. The Physiotherapy session goes well, and the patient performs some simple exercises.

DAY 6: Morning meeting with his Patient Manager, free day to rest. The patient feels quite well.

DAY 7: Morning pick-up by his Patient Manager, check-out and drop-off at Venice airport. The patient feels quite well.

Follow up

SEPTEMBER 2019 (2 month after treatment): the patient is in great pain, very sensible in his foot/leg, and is having problems to sleep. Physiotherapists at home forced him to touch his legs, which was agony for the young boy, and has him develop a sort of phobia of them.

OCTOBER 2019 (3 months after treatment): the patient threw his crunches away and walks on his own! He still has some pain, but he can touch his leg. He finally agreed to go back to physiotherapy.

NOVEMBER 2019 (4 months after treatment): the patient’s mother says that her son is pain free, evidently calmer and, after several months of not going because of the state of his condition, went back to school.


The patient is now completely pain free, and able to go back to school. He walks without the need of crutches anymore, and his mother says he is back to his happy joyful self !

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.