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CRPS Treatment: pain in foot and leg for 6 years and a half

General details and patient's info

Age:34 years old at the time of treatment.
Home Country:USA.
Illness duration:6 years and a half prior to the Neridronate Treatment.
Cause:Climbing accident.
Symptoms:BConstant pain; sensitivity to touch; loss of muscle strength in leg; Pain worsened with activities but the patient still walks without any aid.
Clinical evaluation:CRPS diagnosis.
Time of treatment:Novembre 2021.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient, a very active woman, did not want to resort to spinal cord surgery which was the next step advised by her doctor. Her husband being a physiotherapist, they both preferred non-surgical approach to the disease. He had been following her for 6 years helping her with physiotherapy focused on chronic pain. They discovered Neridronate and agreed it was the best option for the patient.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

3 sessions, 30min each, of Neuromuscular Rehabilitation Treatment with the Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion. Her husband was impressed with the physiotherapy session.

DAY 4: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. Touring of Soave.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion.

DAY 6: Rest day in the hotel, in contact with her Patient Manager.

DAY 7: Morning pick-up by her Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion. Touring of Verona.

DAY 8: Check-out from hotel in Verona, check-in at hotel in Venice, and touring of Venice.

DAY 9: Pick-up by her Patient Manager, check-out and drop-off at the Venice airport for her trip back home.

Follow up

JANUARY 2022 (3 months after Neridronate treatment): the patient said her pain levels are lowering day by day.

MARCH 2022 (5 months after Neridronate treatment): the patient refers to feeling her leg get stronger, pain reduction of 80%.

SEPTEMBER 2023 (10 months after Neridronate treatment): The patient reports being in full remission of all symptoms.


This patient has the luck to be married to a physiotherapist aware of chronic pain conditions, who had been treating her since day 1, which is probably why even with 6 years of CRPS she was walking without aid, and only reported some small muscle weakness.
It also definitely helped her to go into full remission path after the treatment in Italy, as well as the side therapies she had access to during her treatment week.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.