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CRPS Treatment: pain in foot and leg for 6 years

General details and patient's info

Age:51 years old at the time of treatment.
Home Country:Australia.
Illness duration:6 years prior to the Neridronate Treatment.
Cause:Bike accident in which she sprained her ankle.
Symptoms:Swelling; excessive sweating; hair growth abnormality on the leg; sensitivity to touch; pain is described as 8/10 daily: the patient cannot wear shoes.
Clinical evaluation:Complex Regional Pain Syndrome.
Time of treatment:June 2021.

Why the Patient decided to undergo the CRPS Treatment in Italy

This patient’s doctor had encountered another CRPS patient 2 years before, and had studied the disease, which was back then unknown to him, as well as the available treatments for it. He found out about Neridronate and mentioned it to both patients. This woman then easily found us online and contacted us.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Pantoprazole infusions; Paracetamol.

3 sessions Massotherapy Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

9 days Light Therapy (in the hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venezia airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with her Patient Manager.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st infusions.

DAY 4: Morning pick-up by her Patient Manager, 2nd infusions.

DAY 5: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd infusions.

DAY 6: Rest day in the hotel, in contact with her Patient Manager.

DAY 7: Morning pick-up by her Patient Manager. 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th infusions.

DAY 9-10: Rest days.

DAY 11: Pick-up by her Patient Manager, check-out and drop-off at the Venice airport for her trip back home.

Follow up

AUGUST 2021 (2 months after Neridronate treatment): The patient reports her swelling is completely gone. She feels her pain has lowered to 6/10 daily.

NOVEMBER 2021 (5 months after Neridronate treatment): The patient is incredibly happy with her current results. She says her pain levels are at 2/10 and other symptoms seem to ha completely disappeared. She can now wear shoes and is incredibly grateful.

JUNE 2022 (1 year after Neridronate treatment): the patient confirms she is still in near remission, with pain levels only going up to 4/10 during flares up.


This case is a great recovery story. This patient had suffered a lot, for 6 long years. She was not able to wear shoes on her CRPS foot. After the treatment, her pain levels were at their lowest, and she mentioned being at 1 or 2/10 and it reaching 4/10 only during flare-ups

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.