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CRPS Treatment: pain in foot for 11 months

General details and patient's info

Age:33 years old at the time of treatment.
Home Country:United Kingdom.
Illness duration:11 months prior to the Neridronate Treatment.
Cause:None confirmed, suspected multiple steroid injections to treat Morton’s neuroma.
Symptoms:Pain level at the beginning of the condition was 10, then decreased. Foot swells and changes color and temperature. Burning sensation at touch, pins and needles sensation. Cannot move her toes.
Clinical evaluation:CRPS diagnosis. Left foot pain with swelling and some color change. Irritable to light touch, slightly dusky and swollen. Allodynia. Pain aggravated by standing and walking.
Time of treatment:March 2019.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient met more doctors and tried more medications that helped a bit with the pain. However she was not offered a specific treatment in UK. Which is why she did some research and finally decided to get the Neridronate treatment in Italy.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330
Methylprednisolone, Paracetamol.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager and check-in at the hotel in Vicenza.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Neridronate infusion.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. The patient has some side effects, and her foot is swollen.

DAY 4: Free day trip to Venice, in contact with Patient Manager.

DAY 5: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. The patient feels tired.

DAY 6: Morning pick-up by her Patient Manager, last Neridronate infusion and 2nd visit with the Rheumatologist Professor.

DAY 7: Morning pick-up by her Patient Manager, check-out and drop-off at the Venice airport.

Follow up

APRIL 2019 (1 month after treatment): the patient is doing better; she is exercising every day as suggested by the doctor in Italy.

MAY 2019 (2 months after treatment): the patient had further improvements; sensitivity is not so high anymore.

JUNE 2019 (3 months after treatment): symptoms are almost gone, and the patient feels her foot “stronger”.

SEPTEMBER 2019 (6 months after treatment): the patient confirms she has had a general improvement of 85% of her symptoms and even wear heels sometime!


The patient followed her exercise plan after the treatment and months after, confirms she has had a general improvement of 85% of all her symptoms and can even wear heels sometime.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.