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CRPS Treatment: pain in foot for 2 years

General details and patient's info

Gender:Female.
Age:40 years old at the time of treatment.
Home Country:United States of America.
Illness duration:2 years prior to the Neridronate Treatment.
Cause:Foot fracture.
Symptoms:Severe burning pain both day and night. It worsens with walking and activities. Uses a wheelchair.
Clinical evaluation:CRPS diagnosis, following calcaneus fracture and cuboid bone of left foot. Left foot and hip pain.
Time of treatment:February 2017.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient tried several medications without results and she was just referred to palliative care because doctors did not have any other options for her. Due to her excruciating pain, she was also thinking about amputation. She researched online and in 2016 she found that Italy was offering a valid treatment for CRPS. As a mother of 3, she had start a GoFundMe campaign to raise money. That was successful and allowed her to travel to Italy with her husband one year later.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Pantoprazole infusions; Paracetamol.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her first Hotel in Vicenza. Briefing focused on next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Doctor, 1st Neridronate infusion.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. The patient feels a bit weak.

DAY 4: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. The patient feels achy and tired.

DAY 5: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, last Neridronate infusion.

DAY 6: Morning meeting with her Patient Manager, rest day. The patient feels tired, but she is hopeful in the treatment results.

DAY 7: Morning pick-up by her Patient Manager and drop-off at Venice airport.

Follow up

MAY 2017 (3 months after Neridronate treatment): the patient is having slow improvements.

SEPTEMBER 2017 (7 months after Neridronate treatment): the patient feels much better. Unfortunately, she also went through other different health problems such as a pulmonary embolism. However she is off her pain medications, except one and has started walking without the need for a wheelchair or a walker.

AUGUST 2018 (18 months after Neridronate treatment): the patient is in total remission, completely healed: no more medications, no more pain, she walks, and she is back to all her activities.

Conclusion

This patient reached the best possible results, undergoing the Neridronate treatment 2 years after the CRPS onset. She was aware that the outcome of the treatment varies between one patient to another but kept a positive mind and was very optimistic on her results.
A good attitude and positive mood can have a real impact on the results of medical treatments.
The patient is in total remission, completely healed: no more medications, no more pain, she walks, and she is back to all her activities.

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.