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CRPS Treatment: pain in foot for 9 months

General details and patient's info

Age:23 years old at the time of treatment.
Home Country:United States of America.
Illness duration:9 months prior to the Neridronate Treatment.
Symptoms:Constant pain in the foot. Impossible to put the foot on the ground, walking, putting weight on it. Body weight is completely on right side, unbalancing her posture. Knee scooter always needed, cannot climb stairs.
Clinical evaluation:CRPS diagnosis.
Time of treatment:January 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

This young patient got CRPS from an unknown onset. She suddenly could not walk anymore, and she had to quit her job as a children teacher because she could not handle it. She took several medications that helped a bit with the pain but not with the mobility. She researched online to find a solution and she read and listened to the previous MTI patients’ stories and successes, and finally decided to come.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website:
3 sessions Neuromuscular Rehabilitation Treatment with Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her first Hotel in Vicenza. Briefing focused on next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion, visit of Verona center. The patient feels well, she just has a bit of nausea.

DAY 4: Morning pick-up by her Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion, the patient is well but tired. She cooperates with the Physiotherapist and understand the importance of correct breathing.

DAY 5: Morning pick-up by her Patient Manager, lunch with MTI team and visit of Sirmione and Garda Lake, using a wheelchair. The patient is happy and enjoys touring the area.

DAY 6: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor, last Neridronate infusion and 3rd Rehabilitation session.

DAY 7: Rest day, in contact with her Patient Manager. The patient and her father visit Vicenza’s city center.

DAY 8: Morning pick-up by her Patient Manager and drop-off at Venice airport.

Follow up

FEBRUARY 2023 (1 month after Neridronate treatment): the patient is having slow improvements, exercising nearly every day. She is also back at her job, after a long leave due to her pain issues.

APRIL 2023 (3 months after Neridronate treatment): the patient feels much better. She is still using the knee scooter, but she can now put weight on her foot.

MAY 2023 (5 months after Neridronate treatment): the patient started walking without crutches and she is doing better every day.

JULY 2023 (7 months after Neridronate): the patient increased walking several times a day, she can stand on her foot without pain.


This patient was particularly thorough in exercising according to the MTI Physiotherapist suggestions and she is having consistent outcomes, getting better every day. She can now walk without crutches and stand on her foot without having pain.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.