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CRPS Treatment: pain in hand and arm for 1 year and a half

General details and patient's info

Age:37 years old at the time of treatment.
Home Country:United Kingdom.
Illness duration:1 year and a half prior to the Neridronate Treatment.
Cause:Sprained wrist.
Symptoms:Burning, stinging pain. Color changes in hand. Muscle tightness. Hypersensitivity to cold weather.
Clinical evaluation:CRPS diagnosis. Hand is sensitive to light touch. Excessive sweating noticeable. Restricted mobility of the arm.
Time of treatment:April 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient’s rheumatologist was aware of the Neridronate option in Italy and advised him to understand with our team how to start the process of getting him treated here. The patient contacted us quickly, and few months after, he was here for treatment. 

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

3 sessions, 30min each, of Neuromuscular Rehabilitation Treatment with the Physiotherapist.
Rehabilitation therapy is a full body workout which focuses on the general wellbeing of the body, to help the affected limb get back to its normal self.

7 nights Biophysical Treatment (5 hours each night while the patients are asleep)
MTI’s Biophysical Treatment is the outcome of 25 years of research and studies. It has been certified by the best Italian Universities, partners from both public and private teams. The Biophysical treatment acts on the roots of the disease, brings relief to the inflammatory condition, helps the cells regeneration, the oxygenation, the micro-circulation, and the lymphatic system.

Daily Report

DAY 1: Arrival at the Verona airport, greeted by his Patient Manager, followed by check-in at his Hotel in Verona. Briefing focused on the next days.

DAY 2: Rest day in the hotel, in contact with his Patient Manager.

DAY 3: Morning pick-up by his Patient Manager, 1st visit with the Rheumatologist Professor, 1st Rehabilitation session, and 1st Neridronate infusion.

DAY 4: Morning pick-up by his Patient Manager, 2nd Neridronate infusion.

DAY 5: Morning pick-up by his Patient Manager, 2nd Rehabilitation session and 3rd Neridronate infusion.

DAY 6: Rest day in the hotel, in contact with his Patient Manager.

DAY 7: Morning pick-up by his Patient Manager, 2nd visit with Rheumatologist Professor, 3rd Rehabilitation session, 4th Neridronate infusion.

DAY 8: Pick-up by his Patient Manager, check-out and drop-off at the Verona airport for his trip back home.

Follow up

JUNE 2023 (2 months after Neridronate treatment): The patient reports a noticeable improvement in the tightness of his arm’s muscles.

SEPTEMBER 2023 (5 months after Neridronate treatment): Pain level drastically dropped from a 8/10 before treatment to 2/10 after only 5 months.

NOVEMBER 2023 (7 months after Neridronate treatment): Patient reports no more allodynia, nor change of color, and pain is nearly gone, going to 2/10 during flare ups. He says his flare ups are further apart and rarely happen anymore.


This was a successful case for this patient who was fortunately still in a good time-window regarding the administration of the infusions.
His other symptoms are gone, and the pain is nearly gone, going up to 2/10 during flare ups.
He was very thorough with his neuro-musculation plan which helped him manage to regain very good mobility in his arm.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.