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CRPS Treatment: pain in hand for 1 year

General details and patient's info

Age:58 years old at the time of treatment.
Home Country:USA.
Illness duration:1 year prior to the Neridronate Treatment.
Cause:Injury at work, where a heavy plastic piece fell on her left hand.
Symptoms:Knifes sensation, stabbing and throbbing unbearable pain. Spasms, discoloration.
Clinical evaluation:Complex Regional Pain Syndrome Type 1, left index finger and hand, severe pain.
Time of treatment:September 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient did not find great help at home in California; she was offered fans medications, exercising and taping therapy. She also had 3 acupuncture sessions. She was unable to use her left hand and decided to start searching on her own for further possible treatment.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)

See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Pantoprazole infusions; Paracetamol.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her Hotel in Verona. Briefing focused on the next days.

DAY 2: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor and 1st Neridronate infusion.

DAY 3: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. In the afternoon, tourism in Verona with her Patient Manager.

DAY 4: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. In the afternoon, rest in her hotel room.

DAY 5: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor and visit of Vicenza Centre with her Patient manager.

DAY 6: Morning pick-up by her Patient Manager and 4th Neridronate infusion.

DAY 7: Rest day.

DAY 8: Pick-up by her Patient Manager and drop-off at Venice airport.

Follow up

DECEMBER 2023 (2 months after Neridronate treatment): the patient says that she does not experience any more morning spasms; her energy levels are better, and her left hand/wrist/arm range of movements are improving. Body temperature is improving, she is not always feeling warm as it used to be.

JANUARY 2024 (3 months after Neridronate treatment): the patient says that she is at zero pain. She is working on improving her left-hand range of movements.


The patient is getting important outcomes from her treatment in Italy as she currently is in full remission. She keeps working on a healthy lifestyle, exercise, good quality food. She is also very positive, trustful, and hopeful, very much focused on total improvement, which always has a huge impact on recovery.

This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.