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CRPS Treatment: pain in hand for 2 years

General details and patient's info

Gender:Female.
Age:28 years old at the time of treatment.
Home Country:United States of America.
Illness duration:2 years and a half prior to the Neridronate Treatment.
Cause:Hand injury, slammed in car door.
Symptoms:Pain started in hand and moved up the arm, shoulder, neck and jaw. Fire sensation under the skin. Joints hurt with every movement, very limited movement of fingers, cannot lift weight; cold weather and rain increase pain. Activity makes it more painful, swelling. Emotional stress.
Clinical evaluation:CRPS diagnosis. Right hand swelling, shiny, hypoesthesia. Mild anxious mood, mild depression.
Time of treatment:April 2023.

Why the Patient decided to undergo the CRPS Treatment in Italy

The patient tried 5 different treatments and lots of medications to treat both pain and mental issues. All of them showed minimal results. The patient lived on her own and had a job but due to CRPS she could not work anymore and went back to live with her family. Her father researched on alternative options and even though at the beginning he was very concerned about travelling so far, he concluded that it was the best chance for his daughter.

Medical treatment the Patient underwent in Italy

Complex regional pain syndrome (CRPS) is a severely painful and disabling disease for which a multitude of therapeutic interventions have been proposed. In the past two decades, only Bisphosphonates gained credibility. In recent years, more convincing evidence has become available on the use of Parenteral Neridronate. Since 2014, this drug is registered and marketed in Italy for the treatment of CRPS. To date, the only therapeutic schedule that is recognized to be able to confer benefit is the intravenous (IV) administration of 100 mg given 4 times.

4 neridronate infusions (100mg, I.v. in saline Solution 0,9% 250 ml)
See the Official Study on the Oxford Academics website: https://academic.oup.com/rheumatology/article/52/3/534/1777330

4 Pantoprazole infusions; Paracetamol.

8 days Light Therapy (in hotel room, 30+ more minutes each day)
30 minutes or more of usage of the MTI Light Therapy reduces inflammation, increase micro-circulation, relax nerves and muscles, reduces pain transmission, accelerates healing, regenerates cells, and promotes cells activation.

Daily Report

DAY 1: Arrival at the Venice airport, greeted by her Patient Manager, followed by check-in at her first Hotel in Vicenza. Briefing focused on next days. Light therapy has been installed in her hotel room; her Patient Manager has explained all details on how to operate the machine.

DAY 2: Rest day, in contact with her Patient Manager. She then proceeds with Light therapy in her hotel room. The patient enjoys it very much and she uses it for long time.

DAY 3: Morning pick-up by her Patient Manager, 1st visit with the Rheumatologist Professor and 1st Neridronate infusion. The patient feels tired. She then proceeds with Light therapy in her hotel room.

DAY 4: Morning pick-up by her Patient Manager, 2nd Neridronate infusion. The patient feels tired and her bones ache. She is able to take a short walk in Verona and she enjoys it. She then proceeds with Light therapy in her hotel room.

DAY 5: Morning pick-up by her Patient Manager, 3rd Neridronate infusion. The patient still reports bones ache in all body. She then proceeds with Light therapy in her hotel room.

DAY 6: Morning pick-up by her Patient Manager, tour by car of Vicenza and then rest in hotel. She then proceeds with Light therapy in her hotel room.

DAY 7: Morning pick-up by her Patient Manager, 2nd visit with the Rheumatologist Professor and last Neridronate infusion. She then proceeds with Light therapy in her hotel room.

DAY 8: Morning meeting with Patient Manager, rest day. She then proceeds with Light therapy in her hotel room.

DAY 9: Morning pick-up by her Patient Manager and drop-off at Venice airport. The patient felt very tired during the whole stay, and she was resting for a long time. Today she is much better, and she likes to talk, she is positive on the treatment results.

Follow up

JUNE 2023 (2 months after Neridronate treatment): the patient says that the pain is not going down, but her father sees difference and improvements: she does not keep the right arm in a protective posture anymore; when she walks, she often swings the arm instead of keeping it close to her body. Other people also noticed an improved mood.

Conclusion

This patient underwent the Neridronate treatment recently, we keep following her and we expect more improvements.

DISCLAIMER
This is not a medical case study; it merely describes each patient’s journey, and it omits all personal data. The people who redacted it are not doctors but all the facts reported are objective and represent the patient’s reality thanks to the information in our possession. The report is not part of any clinical trials. It was written to provide more information to patients who have made multiple requests for treatment outcomes of cases like theirs.